ID   NS1BB_DANRE             Reviewed;         640 AA.
AC   Q7ZVQ8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Influenza virus NS1A-binding protein homolog B;
DE            Short=NS1-BP homolog B;
DE            Short=NS1-binding protein homolog B;
GN   Name=ivns1abpb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in cell division and in the dynamic organization
CC       of the actin skeleton as a stabilizer of actin filaments by association
CC       with F-actin through Kelch repeats. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
CC       Note=Associated with actin filaments. {ECO:0000250}.
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DR   EMBL; BC045449; AAH45449.1; -; mRNA.
DR   RefSeq; NP_958891.1; NM_201483.1.
DR   AlphaFoldDB; Q7ZVQ8; -.
DR   SMR; Q7ZVQ8; -.
DR   STRING; 7955.ENSDARP00000002476; -.
DR   PaxDb; Q7ZVQ8; -.
DR   GeneID; 334334; -.
DR   KEGG; dre:334334; -.
DR   CTD; 334334; -.
DR   ZFIN; ZDB-GENE-030131-6266; ivns1abpb.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q7ZVQ8; -.
DR   OrthoDB; 251780at2759; -.
DR   PhylomeDB; Q7ZVQ8; -.
DR   PRO; PR:Q7ZVQ8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Kelch repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..640
FT                   /note="Influenza virus NS1A-binding protein homolog B"
FT                   /id="PRO_0000285080"
FT   DOMAIN          32..100
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          135..186
FT                   /note="BACK"
FT   REPEAT          366..412
FT                   /note="Kelch 1"
FT   REPEAT          413..460
FT                   /note="Kelch 2"
FT   REPEAT          462..509
FT                   /note="Kelch 3"
FT   REPEAT          510..556
FT                   /note="Kelch 4"
FT   REPEAT          557..603
FT                   /note="Kelch 5"
FT   REPEAT          605..640
FT                   /note="Kelch 6"
FT   REGION          257..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  71118 MW;  DC6CF9C2438A1D81 CRC64;
     MTPNGYLIFE DESFLDSTVA KMNALRKSGQ FCDVRLLVCG HELMAHKAVL ACCSPYLFEI
     FNADTEPQGG VSLVKFDDLN PDAMEVLLNY AYTAQLKADK SLVSDVYSAA KKLKLERVKQ
     ICGEYLLSKM DSQSAISYRN FASSMADGRL LGKIDGYIQD HLHEISEQDD FLKLPRLKLE
     VMLEDNLNLP GNGKLYSKVI SWVQRSLWKN GDPLEKLMEE VQTLYYSADH KLHDGSLLEG
     QAEVCSTEDD HIQFVQKKPP RERDEMGSGA SGSISPSNSQ FNKHEWKYIA SEKTTSNSYL
     CLAVLRGLLC VISLHGRTSP HNSPSATPCV LKSPNFEAQL EDLQEKLLKP MHYARSGLGT
     AELDCKLIAA GGYNREECLR TVECYDPKKD CWTFIAPMRT PRARFQMAVL MGEVYVMGGS
     NGHSDELSCG EMYNPRADEW IQVPELRTNR CNAGVCSLQN KLFVVGGSDP CGQKGLKNCD
     SFDPVTKMWT SCAPLNIKRH QAAVCELSGY MYVIGGAESW NCLNSVERYN PENNTWTLVA
     SMNVARRGAG VAVYEGKLFV VGGFDGSHAL RCVEVYDPAT NEWRMLGSMT SARSNAGLAV
     LNNVLCAVGG FDGNEFLNSM EVYNLEKNEW SPFIEALGKN