ID   NS1BP_XENLA             Reviewed;         638 AA.
AC   Q6DFU2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Influenza virus NS1A-binding protein homolog;
DE            Short=NS1-BP;
DE            Short=NS1-binding protein homolog;
GN   Name=ivns1abp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in cell division and in the dynamic organization
CC       of the actin skeleton as a stabilizer of actin filaments by association
CC       with F-actin through Kelch repeats. {ECO:0000250|UniProtKB:Q920Q8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
CC       Note=Associated with actin filaments. {ECO:0000250}.
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DR   EMBL; BC076641; AAH76641.1; -; mRNA.
DR   RefSeq; NP_001086493.1; NM_001093024.1.
DR   AlphaFoldDB; Q6DFU2; -.
DR   SMR; Q6DFU2; -.
DR   DNASU; 446327; -.
DR   GeneID; 446327; -.
DR   KEGG; xla:446327; -.
DR   CTD; 446327; -.
DR   Xenbase; XB-GENE-949337; ivns1abp.L.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446327; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 2.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Kelch repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..638
FT                   /note="Influenza virus NS1A-binding protein homolog"
FT                   /id="PRO_0000285081"
FT   DOMAIN          32..99
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          134..233
FT                   /note="BACK"
FT   REPEAT          365..411
FT                   /note="Kelch 1"
FT   REPEAT          412..459
FT                   /note="Kelch 2"
FT   REPEAT          461..508
FT                   /note="Kelch 3"
FT   REPEAT          509..555
FT                   /note="Kelch 4"
FT   REPEAT          557..602
FT                   /note="Kelch 5"
FT   REPEAT          604..638
FT                   /note="Kelch 6"
FT   REGION          251..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  71018 MW;  B231CD42AC49AFF1 CRC64;
     MIPNGSLNFE DEQFIESSVA KLNALRKSGQ FCDVKLQVCG HEMLAHRAVL ACCSPFLFEI
     FNSDSESNGI SLVRFDDLNP EAVEVLLNYA YTSQLKAETD LVKDVYSAAK KLKIDRVKQV
     CGDYLISKID AQSGISCRNF VNTMGDWRLL TKIDNYIQEH LLEISEQDDF LKLPRLNLEI
     MLEENVSLPS NGKLYTKVIN WVQRSIWENG ENLDALMEEV QTLYYSADHK LLDGSSLGEH
     TEAHEDNIQL IQKKSPRENN HKNLISSSSG SLSPSALIQC PKHEWKIIAS EKKTNNTYLC
     LAVLNSTLCV IFLHGRNSPV NSPSSTPRLT KSLSLEIQPE DSLERVMSPM HYARSGLGTA
     ELNGKLIAAG GYNREECLRT VECYDLETDI WTFIAPMKTP RARFQMAVLM DHLYVVGGSN
     GHSDDLSCGE KYDPKSNIWT PVPELRSNRC NAGVCALNGN LYVVGGSDPY GQKGLKNCDV
     FNPITRMWTC CAQLNIRRHQ PAVCELGNKI YIIGGAESWN CLNSVECYNP QNDTWTLVAP
     MNVARRGSGV AVYDGKLLVV GGFDGTHALC CVESYNPERN EWKMVGSMTS SRSNAGVVAV
     GNQIYAAGGF DGNEFLNTVE VYNPQTDEWS PFTQLCES