ID   AROK_HALSA              Reviewed;         284 AA.
AC   Q9HQB0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Shikimate kinase;
DE            Short=SK;
DE            EC=2.7.1.71;
GN   Name=aroK; OrderedLocusNames=VNG_1245C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + shikimate = 3-phosphoshikimate + ADP + H(+);
CC         Xref=Rhea:RHEA:13121, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36208, ChEBI:CHEBI:145989, ChEBI:CHEBI:456216;
CC         EC=2.7.1.71;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       5/7.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Archaeal shikimate
CC       kinase subfamily. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19605.1; -; Genomic_DNA.
DR   PIR; A84280; A84280.
DR   RefSeq; WP_010902901.1; NC_002607.1.
DR   AlphaFoldDB; Q9HQB0; -.
DR   SMR; Q9HQB0; -.
DR   STRING; 64091.VNG_1245C; -.
DR   PaxDb; Q9HQB0; -.
DR   EnsemblBacteria; AAG19605; AAG19605; VNG_1245C.
DR   GeneID; 5954102; -.
DR   KEGG; hal:VNG_1245C; -.
DR   PATRIC; fig|64091.14.peg.953; -.
DR   HOGENOM; CLU_073768_0_0_2; -.
DR   InParanoid; Q9HQB0; -.
DR   OMA; WDVLVWT; -.
DR   OrthoDB; 98200at2157; -.
DR   PhylomeDB; Q9HQB0; -.
DR   UniPathway; UPA00053; UER00088.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004765; F:shikimate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   HAMAP; MF_00370; Shik_kinase_arch; 1.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR010189; SK_arc.
DR   PANTHER; PTHR20861:SF3; PTHR20861:SF3; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF005758; Shikimt_kin_arch; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   TIGRFAMs; TIGR01920; Shik_kin_archae; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding;
KW   Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..284
FT                   /note="Shikimate kinase"
FT                   /id="PRO_0000141572"
FT   BINDING         85..95
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  28646 MW;  F14CD2A7152E6C68 CRC64;
     MDGRAVAPAA GTVLNALATG VGAAFALDID TEASVSVTPS ESGVSGEIAG HPEADTALVE
     RCVSRVIDRY GDGQGGHVRT ESEVPLAAGL KSSSAAANAT VLATLDALGV ADEVDRVDAA
     RLGVQAARDA GVTVTGAFDD AAASMLGGVA MTDNREDDLL FRDAVEWHAA VWTPPERAYS
     ADADVARCER VSGLAEHVAA LAAAGDYGTA MTVNGLAFCA ALDFPTAPAV TALPHAAGVS
     LSGTGPSYVA VGDEDGIEEV STRWHENPGT VRETTTQLAG ARTT