NS1_INCAA
ID NS1_INCAA Reviewed; 246 AA.
AC Q01639; A7BHX8; Q9YMF4; Q9YMF5;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 2.
DT 23-FEB-2022, entry version 78.
DE RecName: Full=Non-structural protein 1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE Short=NS1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE AltName: Full=NS1A {ECO:0000255|HAMAP-Rule:MF_04066};
GN Name=NS {ECO:0000255|HAMAP-Rule:MF_04066};
OS Influenza C virus (strain C/Ann Arbor/1/1950).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX NCBI_TaxID=11553;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND IDENTIFICATION OF
RP FRAMESHIFT.
RC STRAIN=C/Ann Arbor/1/50-pi, and Wild-type;
RX PubMed=9918879; DOI=10.1006/viro.1998.9456;
RA Marschall M., Helten A., Hechtfischer A., Zach A., Banaschewski C.,
RA Hell W., Meier-Ewert H.;
RT "The ORF, regulated synthesis, and persistence-specific variation of
RT influenza C viral NS1 protein.";
RL Virology 253:208-218(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17537859; DOI=10.1128/jvi.00075-07;
RA Muraki Y., Murata T., Takashita E., Matsuzaki Y., Sugawara K., Hongo S.;
RT "A mutation on influenza C virus M1 protein affects virion morphology by
RT altering the membrane affinity of the protein.";
RL J. Virol. 81:8766-8773(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 6-241.
RX PubMed=2943076; DOI=10.1016/0042-6822(86)90003-6;
RA Buonagurio D.A., Nakada S., Fitch W.M., Palese P.;
RT "Epidemiology of influenza C virus in man: multiple evolutionary lineages
RT and low rate of change.";
RL Virology 153:12-21(1986).
RN [4]
RP IDENTIFICATION OF FRAMESHIFT.
RX PubMed=10900030; DOI=10.1099/0022-1317-81-8-1933;
RA Alamgir A.S.M., Matsuzaki Y., Hongo S., Tsuchiya E., Sugawara K.,
RA Muraki Y., Nakamura K.;
RT "Phylogenetic analysis of influenza C virus nonstructural (NS) protein
RT genes and identification of the NS2 protein.";
RL J. Gen. Virol. 81:1933-1940(2000).
CC -!- FUNCTION: Prevents the establishment of the cellular antiviral state
CC initiated by host DDX58, which normally triggers the antiviral
CC transduction signal that leads to the activation of type I IFN genes by
CC transcription factors IRF3 and IRF7. Participates also in the up-
CC regulation of the splicing of viral mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_04066}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04066,
CC ECO:0000269|PubMed:9918879}. Host nucleus {ECO:0000255|HAMAP-
CC Rule:MF_04066, ECO:0000269|PubMed:9918879}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NS1;
CC IsoId=Q01639-1; Sequence=Displayed;
CC Name=NEP; Synonyms=NS2;
CC IsoId=Q01640-1; Sequence=External;
CC -!- PTM: The NS1 protein of strain C/Ann Arbor/1/50-pi is phosphorylated.
CC -!- MISCELLANEOUS: The strain C/Ann Arbor/1/50-pi causes persistent
CC infection.
CC -!- SIMILARITY: Belongs to the influenza C viruses NS1 family.
CC {ECO:0000255|HAMAP-Rule:MF_04066}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA24044.1; Type=Frameshift;
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DR EMBL; AF102026; AAC98304.1; -; mRNA.
DR EMBL; AF102027; AAC98305.1; -; mRNA.
DR EMBL; AB283001; BAF74590.1; -; Viral_cRNA.
DR EMBL; D00029; BAA24044.1; ALT_FRAME; Genomic_RNA.
DR RefSeq; YP_002302329.1; NC_006306.2.
DR IntAct; Q01639; 1.
DR DNASU; 3077236; -.
DR GeneID; 3077236; -.
DR KEGG; vg:3077236; -.
DR Proteomes; UP000008286; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
DR HAMAP; MF_04066; INFV_NS1; 1.
DR InterPro; IPR005187; Flu_C_NS1.
DR InterPro; IPR005188; Flu_C_NS2.
DR InterPro; IPR004208; NS1.
DR Pfam; PF03506; Flu_C_NS1; 1.
DR Pfam; PF03555; Flu_C_NS2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Host cytoplasm; Host nucleus; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW Interferon antiviral system evasion; Reference proteome; RNA-binding;
KW Viral immunoevasion.
FT CHAIN 1..246
FT /note="Non-structural protein 1"
FT /id="PRO_0000044588"
FT VARIANT 39
FT /note="T -> K (in strain: C/Ann Arbor/1/50-pi)"
FT VARIANT 46
FT /note="R -> K"
FT VARIANT 74
FT /note="T -> A"
FT VARIANT 84
FT /note="V -> I (in strain: C/Ann Arbor/1/50-pi)"
FT VARIANT 96
FT /note="A -> T (in strain: C/Ann Arbor/1/50-pi)"
FT VARIANT 98
FT /note="S -> R"
FT VARIANT 179
FT /note="K -> R"
FT VARIANT 189
FT /note="R -> K (in strain: C/Ann Arbor/1/50-pi)"
FT VARIANT 228
FT /note="K -> T"
FT VARIANT 232
FT /note="D -> N (in strain: C/Ann Arbor/1/50-pi)"
SQ SEQUENCE 246 AA; 27752 MW; 3478E6665209C621 CRC64;
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS FAPRTWEDAI
KDGELLFNGT ILQTESPTMT PASVEMKGKK FPIDFAPSNI APIGQNPIYL SPCIPNFDGN
VWEATMYHHR GATLTKTMNC NCFQRTIWCH PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ
VAGIETGIRK CFRCIKSGFV MATDEISLTI LQSIKSGAQL DPYWGNEKPD IDKTEAYMLS
LREAGP