ID   NS1_INCCA               Reviewed;         246 AA.
AC   P06944; Q68BV4;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 2.
DT   23-FEB-2022, entry version 68.
DE   RecName: Full=Non-structural protein 1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE            Short=NS1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE   AltName: Full=NS1A {ECO:0000255|HAMAP-Rule:MF_04066};
GN   Name=NS {ECO:0000255|HAMAP-Rule:MF_04066};
OS   Influenza C virus (strain C/California/1978).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX   NCBI_TaxID=203224;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=4032535; DOI=10.1128/jvi.56.1.221-226.1985;
RA   Nakada S., Graves P.N., Desselberger U., Creager R.S., Krystal M.,
RA   Palese P.;
RT   "Influenza C virus RNA 7 codes for a nonstructural protein.";
RL   J. Virol. 56:221-226(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15310173; DOI=10.1017/s0950268804002146;
RA   Matsuzaki Y., Takao S., Shimada S., Mizuta K., Sugawara K., Takashita E.,
RA   Muraki Y., Hongo S., Nishimura H.;
RT   "Characterization of antigenically and genetically similar influenza C
RT   viruses isolated in Japan during the 1999-2000 season.";
RL   Epidemiol. Infect. 132:709-720(2004).
CC   -!- FUNCTION: Prevents the establishment of the cellular antiviral state
CC       initiated by host DDX58, which normally triggers the antiviral
CC       transduction signal that leads to the activation of type I IFN genes by
CC       transcription factors IRF3 and IRF7. Participates also in the up-
CC       regulation of the splicing of viral mRNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_04066}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04066}.
CC       Host nucleus {ECO:0000255|HAMAP-Rule:MF_04066}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=NS1;
CC         IsoId=P06944-1; Sequence=Displayed;
CC       Name=NEP; Synonyms=NS2;
CC         IsoId=P33493-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza C viruses NS1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_04066}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA43780.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M10087; AAA43780.1; ALT_FRAME; Genomic_RNA.
DR   EMBL; AB099625; BAD37133.1; -; Genomic_RNA.
DR   PIR; A25320; MNIVC7.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
DR   HAMAP; MF_04066; INFV_NS1; 1.
DR   InterPro; IPR005187; Flu_C_NS1.
DR   InterPro; IPR005188; Flu_C_NS2.
DR   InterPro; IPR004208; NS1.
DR   Pfam; PF03506; Flu_C_NS1; 1.
DR   Pfam; PF03555; Flu_C_NS2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW   Interferon antiviral system evasion; RNA-binding; Viral immunoevasion.
FT   CHAIN           1..246
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000044586"
SQ   SEQUENCE   246 AA;  27739 MW;  0C6CD2063F16B4E7 CRC64;
     MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS FAPRTWEDAI
     KDGELLFNGT ILQAESTTMT PASVEMKGKK FPIDFVPSNI APIGQNPIYL SPCIPNFDGN
     VWEATMYHHR GATLTKTMNC NCFQRTIWCH PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ
     VAGIETGIRK CFRCIKSGFV MATDEISLII LQSIKSGAQL DPYWGNETPD IDKTEAYMLS
     LREAGP