ID   NS1_INCGL               Reviewed;         241 AA.
AC   P0C134; P06822; Q84088; Q89422;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   07-OCT-2020, entry version 30.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NS1;
DE   AltName: Full=NS1C;
DE   Flags: Fragment;
GN   Name=NS;
OS   Influenza C virus (strain C/Great lakes/1167/1954).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX   NCBI_TaxID=11557;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2943076; DOI=10.1016/0042-6822(86)90003-6;
RA   Buonagurio D.A., Nakada S., Fitch W.M., Palese P.;
RT   "Epidemiology of influenza C virus in man: multiple evolutionary lineages
RT   and low rate of change.";
RL   Virology 153:12-21(1986).
RN   [2]
RP   IDENTIFICATION OF FRAMESHIFT.
RX   PubMed=10900030; DOI=10.1099/0022-1317-81-8-1933;
RA   Alamgir A.S.M., Matsuzaki Y., Hongo S., Tsuchiya E., Sugawara K.,
RA   Muraki Y., Nakamura K.;
RT   "Phylogenetic analysis of influenza C virus nonstructural (NS) protein
RT   genes and identification of the NS2 protein.";
RL   J. Gen. Virol. 81:1933-1940(2000).
CC   -!- FUNCTION: Suppresses the RNA silencing-based antiviral response in
CC       Drosophila cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=NS1;
CC         IsoId=P0C134-1; Sequence=Displayed;
CC       Name=NEP; Synonyms=NS2;
CC         IsoId=P0C135-1; Sequence=External;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA43803.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D00030; BAA24036.1; ALT_FRAME; Genomic_RNA.
DR   EMBL; M15089; AAA43803.1; ALT_FRAME; Genomic_RNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005187; Flu_C_NS1.
DR   InterPro; IPR005188; Flu_C_NS2.
DR   Pfam; PF03506; Flu_C_NS1; 1.
DR   Pfam; PF03555; Flu_C_NS2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host nucleus.
FT   CHAIN           1..241
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000039176"
FT   NON_TER         1
SQ   SEQUENCE   241 AA;  27180 MW;  17AD10720E345EE7 CRC64;
     VKSTNLMAFV ATKMLERQED LDTCTEMQVE KMKTSTKARL RTESSFAPRT WEDAIKDGEL
     LFNGTILQAE SPTMTPASVE MKGKKFPIDF APSNIAPIGQ NPIYLSPCIP NFDGNVWEAT
     MYHHRGATLT KTMNCNCFQR TIWCHPNSSR MRLSYAFVLY CRNTKKICGY LIARQVAGIE
     TGIRKCFRCI KSGFVMATDE ISLTILQSIK SGAQLDPYWG NETPDIDKTE AYMLSLRETG
     P