NS1_INCJH
ID NS1_INCJH Reviewed; 241 AA.
AC P0C136; P06823; Q67405; Q84090;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 07-OCT-2020, entry version 31.
DE RecName: Full=Non-structural protein 1;
DE Short=NS1;
DE AltName: Full=NS1C;
DE Flags: Fragment;
GN Name=NS;
OS Influenza C virus (strain C/Johannesburg/1/1966).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX NCBI_TaxID=100673;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2943076; DOI=10.1016/0042-6822(86)90003-6;
RA Buonagurio D.A., Nakada S., Fitch W.M., Palese P.;
RT "Epidemiology of influenza C virus in man: multiple evolutionary lineages
RT and low rate of change.";
RL Virology 153:12-21(1986).
RN [2]
RP FUNCTION AS A SUPPRESSOR OF RNA SILENCING.
RX PubMed=14745017; DOI=10.1073/pnas.0308308100;
RA Li W.-X., Li H., Lu R., Li F., Dus M., Atkinson P., Brydon E.W.A.,
RA Johnson K.L., Garcia-Sastre A., Ball L.A., Palese P., Ding S.-W.;
RT "Interferon antagonist proteins of influenza and vaccinia viruses are
RT suppressors of RNA silencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1350-1355(2004).
CC -!- FUNCTION: Suppresses the RNA silencing-based antiviral response in
CC Drosophila cells. {ECO:0000269|PubMed:14745017}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NS1;
CC IsoId=P0C136-1; Sequence=Displayed;
CC Name=NEP; Synonyms=NS2;
CC IsoId=P0C137-1; Sequence=External;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA24038.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D00031; BAA24038.1; ALT_FRAME; Genomic_RNA.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR005187; Flu_C_NS1.
DR InterPro; IPR005188; Flu_C_NS2.
DR Pfam; PF03506; Flu_C_NS1; 1.
DR Pfam; PF03555; Flu_C_NS2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Host cytoplasm; Host nucleus.
FT CHAIN 1..241
FT /note="Non-structural protein 1"
FT /id="PRO_0000039178"
FT NON_TER 1
SQ SEQUENCE 241 AA; 27160 MW; 3A82DEFDDE376DE4 CRC64;
VKSTNLMAFV ATKMLERQED LDTCTEMQVE KMKTSTKARL RTESSFAPRT WEDAIKDGEL
LFNGTILQAE SPTMTPASVE MKGKKFPIDF APSNIAPIGQ NPIYLSPCIP NFDGNVWEAT
MYHHRGATLT KTMNCNCFQR TIWCHPNPSR MRLSYAFVLY CRNTKKICGY LIARQVAGIE
TGIRKCFRCI KSGFVMATDE ISLTILQSIK SGAQLDPYWG NETPDIDKTE AYMLSLREAG
P