NS1_INCY6
ID NS1_INCY6 Reviewed; 246 AA.
AC Q784P6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 23-FEB-2022, entry version 33.
DE RecName: Full=Non-structural protein 1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE Short=NS1 {ECO:0000255|HAMAP-Rule:MF_04066};
DE AltName: Full=NS1A {ECO:0000255|HAMAP-Rule:MF_04066};
GN Name=NS {ECO:0000255|HAMAP-Rule:MF_04066};
OS Influenza C virus (strain C/Yamagata/1964).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX NCBI_TaxID=217166;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=10900030; DOI=10.1099/0022-1317-81-8-1933;
RA Alamgir A.S.M., Matsuzaki Y., Hongo S., Tsuchiya E., Sugawara K.,
RA Muraki Y., Nakamura K.;
RT "Phylogenetic analysis of influenza C virus nonstructural (NS) protein
RT genes and identification of the NS2 protein.";
RL J. Gen. Virol. 81:1933-1940(2000).
CC -!- FUNCTION: Prevents the establishment of the cellular antiviral state
CC initiated by host DDX58, which normally triggers the antiviral
CC transduction signal that leads to the activation of type I IFN genes by
CC transcription factors IRF3 and IRF7. Participates also in the up-
CC regulation of the splicing of viral mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_04066}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04066}.
CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04066}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NS1;
CC IsoId=Q784P6-1; Sequence=Displayed;
CC Name=NEP; Synonyms=NS2;
CC IsoId=Q9ENZ3-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the influenza C viruses NS1 family.
CC {ECO:0000255|HAMAP-Rule:MF_04066}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB034155; BAB12049.1; -; Genomic_RNA.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
DR HAMAP; MF_04066; INFV_NS1; 1.
DR InterPro; IPR005187; Flu_C_NS1.
DR InterPro; IPR005188; Flu_C_NS2.
DR InterPro; IPR004208; NS1.
DR Pfam; PF03506; Flu_C_NS1; 1.
DR Pfam; PF03555; Flu_C_NS2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Host cytoplasm; Host nucleus; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW Interferon antiviral system evasion; RNA-binding; Viral immunoevasion.
FT CHAIN 1..246
FT /note="Non-structural protein 1"
FT /id="PRO_0000223626"
SQ SEQUENCE 246 AA; 27695 MW; C1625ABA89A3672A CRC64;
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS FAPRTWEDAI
KDGELLFNGT ILQAESPTMT PASVEMKGKK FPIDFAPSNI APIGQNPIYL SPCIPNFDGN
VWEATMYHHR GATLTKTMNC NCFQRTIWCH PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ
VAGIETGIRK CFRCIKSGFV MATDEISLTI LQSIKSGAQL DPYWGNETPD IDKTEAYMLS
LREAGP