ID   NS1_INCYA               Reviewed;         241 AA.
AC   P0C141; P06825; Q84095; Q84096;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   07-OCT-2020, entry version 29.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NS1;
DE   AltName: Full=NS1C;
DE   Flags: Fragment;
GN   Name=NS;
OS   Influenza C virus (strain C/Yamagata/10/1981).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus.
OX   NCBI_TaxID=11568;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2943076; DOI=10.1016/0042-6822(86)90003-6;
RA   Buonagurio D.A., Nakada S., Fitch W.M., Palese P.;
RT   "Epidemiology of influenza C virus in man: multiple evolutionary lineages
RT   and low rate of change.";
RL   Virology 153:12-21(1986).
CC   -!- FUNCTION: Suppresses the RNA silencing-based antiviral response in
CC       Drosophila cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=NS1;
CC         IsoId=P0C141-1; Sequence=Displayed;
CC       Name=NEP; Synonyms=NS2;
CC         IsoId=P0C142-1; Sequence=External;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA24042.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D00033; BAA24042.1; ALT_FRAME; Genomic_RNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005187; Flu_C_NS1.
DR   InterPro; IPR005188; Flu_C_NS2.
DR   Pfam; PF03506; Flu_C_NS1; 1.
DR   Pfam; PF03555; Flu_C_NS2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host nucleus.
FT   CHAIN           1..241
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000039182"
FT   NON_TER         1
SQ   SEQUENCE   241 AA;  27114 MW;  36493263B3FFD5C3 CRC64;
     VKSTNLMAFV ATKMLERQED LDTCTEMQVE KMKASTKARL RTESSFAPRT WEDAIKDGEL
     LFNGTILQAE SPTMTLASVE MKGKKSPIDF APSNIAPIGQ NPIYLSPCIP NFDGNVWEAT
     MYHHRGATLT KTMNCNCFQR TIWCHPNPSR MRLSYAFVLY CRNTKKICGY LIARQVAGIE
     TGIRKCFRCI KSGFVMATDE ISLTILRSIK SGAQLDPYWG NETPDIDKTE AYMLSLREAG
     P