ID   NS1_ISAV8               Reviewed;         256 AA.
AC   Q8V3U2;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   07-OCT-2020, entry version 33.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NS1;
DE   AltName: Full=Protein P4;
DE            Short=P4;
GN   Name=Segment-7 {ECO:0000303|PubMed:20979983}; ORFNames=s7ORF1;
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND FUNCTION.
RX   PubMed=11807235; DOI=10.1099/0022-1317-83-2-421;
RA   Clouthier S.C., Rector T., Brown N.E., Anderson E.D.;
RT   "Genomic organization of infectious salmon anaemia virus.";
RL   J. Gen. Virol. 83:421-428(2002).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16202469; DOI=10.1016/j.virusres.2005.08.005;
RA   McBeath A.J., Collet B., Paley R., Duraffour S., Aspehaug V., Biering E.,
RA   Secombes C.J., Snow M.;
RT   "Identification of an interferon antagonist protein encoded by segment 7 of
RT   infectious salmon anaemia virus.";
RL   Virus Res. 115:176-184(2006).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18304672; DOI=10.1016/j.virusres.2008.01.008;
RA   Garcia-Rosado E., Markussen T., Kileng O., Baekkevold E.S., Robertsen B.,
RA   Mjaaland S., Rimstad E.;
RT   "Molecular and functional characterization of two infectious salmon anaemia
RT   virus (ISAV) proteins with type I interferon antagonizing activity.";
RL   Virus Res. 133:228-238(2008).
RN   [4]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
RN   [5]
RP   ALTERNATIVE SPLICING.
RX   PubMed=23850870; DOI=10.1016/j.virusres.2013.07.001;
RA   Ramly R.B., Olsen C.M., Braaen S., Rimstad E.;
RT   "Infectious salmon anaemia virus nuclear export protein is encoded by a
RT   spliced gene product of genomic segment 7.";
RL   Virus Res. 177:1-10(2013).
CC   -!- FUNCTION: Plays a role in inhibition of the host innate immune system
CC       by counteracting the type I interferon signaling.
CC       {ECO:0000269|PubMed:16202469, ECO:0000269|PubMed:18304672}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000269|PubMed:18304672}. Host cytoplasm
CC       {ECO:0000269|PubMed:16202469, ECO:0000269|PubMed:18304672}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Non-structural protein 1;
CC         IsoId=Q8V3U2-1; Sequence=Displayed;
CC       Name=Nuclear export protein {ECO:0000269|PubMed:23850870};
CC         IsoId=Q8V3U1-1; Sequence=External;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF404341; AAL67956.1; -; Genomic_RNA.
DR   EMBL; AF429989; AAN57723.1; -; Genomic_RNA.
DR   RefSeq; YP_145798.1; NC_006498.1.
DR   GeneID; 5075850; -.
DR   KEGG; vg:5075850; -.
DR   Proteomes; UP000008772; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Alternative splicing; Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Reference proteome; Viral immunoevasion.
FT   CHAIN           1..256
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000403922"
SQ   SEQUENCE   256 AA;  28604 MW;  FEE8282488010E94 CRC64;
     MSGFNFEVMV PEQGGKVVFS LTETGSCVSF YGDDEPGEGS CELASENMDF PSCPLGNGDD
     FCLSLALSTM RWSGMTKRNN FMDRFIGSFV HCTPVMIWSY GNLSKKSHHK MVCHTCPDEY
     KFSDKDEMQG YYEECLEAST DIFLDELATV VTGGFFPVGL KGSWGGWYLK YVRYAGPLAG
     SSGFIVNQRF YDRAQNKTGS RVVSMVEMDG DGLSFIYEKP SVYHSDGCTG SAARFWKRDH
     NERAGVELRA GLHFRM