ID   NS1_MPV15               Reviewed;         113 AA.
AC   P28888; Q5MKN0;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Non-structural protein 1;
DE   AltName: Full=Non-structural protein 1C;
GN   Name=1C; Synonyms=NS1;
OS   Murine pneumonia virus (strain 15) (MPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.
OX   NCBI_TaxID=296738;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1919530; DOI=10.1099/0022-1317-72-10-2545;
RA   Chambers P., Pringle C.R., Easton A.J.;
RT   "Genes 1 and 2 of pneumonia virus of mice encode proteins which have little
RT   homology with the 1C and 1B proteins of human respiratory syncytial
RT   virus.";
RL   J. Gen. Virol. 72:2545-2549(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15604443; DOI=10.1099/vir.0.80315-0;
RA   Thorpe L.C., Easton A.J.;
RT   "Genome sequence of the non-pathogenic strain 15 of pneumonia virus of mice
RT   and comparison with the genome of the pathogenic strain J3666.";
RL   J. Gen. Virol. 86:159-169(2005).
RN   [3]
RP   FUNCTION.
RX   PubMed=19052095; DOI=10.1128/jvi.02041-08;
RA   Buchholz U.J., Ward J.M., Lamirande E.W., Heinze B., Krempl C.D.,
RA   Collins P.L.;
RT   "Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of
RT   mice attenuates viral replication and reduces pulmonary cytokine expression
RT   and disease.";
RL   J. Virol. 83:1969-1980(2009).
CC   -!- FUNCTION: May play a minor role in antagonizing the type I IFN-mediated
CC       antiviral response (Probable). Additionally, NS1 may serve some
CC       inhibitory role in viral transcription and RNA replication (By
CC       similarity). {ECO:0000250|UniProtKB:P0DOE9,
CC       ECO:0000305|PubMed:19052095}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P0DOE9}.
CC       Host mitochondrion {ECO:0000250|UniProtKB:P0DOE9}. Note=Most NS1
CC       resides in the mitochondria as a heteromer with NS2.
CC       {ECO:0000250|UniProtKB:P0DOE9}.
CC   -!- SIMILARITY: Belongs to the pneumovirus non-structural protein 1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY743910; AAW02832.1; -; Genomic_RNA.
DR   PIR; JQ1255; MNNZ1G.
DR   Proteomes; UP000133604; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host mitochondrion; Interferon antiviral system evasion;
KW   Reference proteome.
FT   CHAIN           1..113
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000142807"
SQ   SEQUENCE   113 AA;  12905 MW;  64E9A94EF6DBB721 CRC64;
     MGCNVMMELD YGGRAAWLAF HITNFDRSDL ETILRGARVC NTWQDQRLSV YLVGRDCNLL
     RPFVQAAKFI HNTRRGQTLT HWFTKNIVFS STGQETEPPI DPTCELLVEL ISG