NS2A_CVHOC
ID NS2A_CVHOC Reviewed; 278 AA.
AC Q80872; Q6TNG1;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Non-structural protein 2a;
DE Short=ns2a;
DE AltName: Full=32 kDa accessory protein;
DE AltName: Full=32 kDa non-structural protein;
DE AltName: Full=ns2;
GN ORFNames=2a;
OS Human coronavirus OC43 (HCoV-OC43).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Embecovirus.
OX NCBI_TaxID=31631;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX PubMed=7844564; DOI=10.1099/0022-1317-76-2-431;
RA Labonte P., Mounir S., Talbot P.J.;
RT "Sequence and expression of the ns2 protein gene of human coronavirus
RT OC43.";
RL J. Gen. Virol. 76:431-435(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate ATCC VR-759;
RX PubMed=15650185; DOI=10.1128/jvi.79.3.1595-1604.2005;
RA Vijgen L., Keyaerts E., Moes E., Thoelen I., Wollants E., Lemey P.,
RA Vandamme A.M., Van Ranst M.;
RT "Complete genomic sequence of human coronavirus OC43: molecular clock
RT analysis suggests a relatively recent zoonotic coronavirus transmission
RT event.";
RL J. Virol. 79:1595-1604(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate 19572 Belgium 2004, and Isolate 87309 Belgium 2003;
RX PubMed=15914223; DOI=10.1016/j.virol.2005.04.010;
RA Vijgen L., Keyaerts E., Lemey P., Moes E., Li S., Vandamme A.M.,
RA Van Ranst M.;
RT "Circulation of genetically distinct contemporary human coronavirus OC43
RT strains.";
RL Virology 337:85-92(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate ATCC VR-759, and Isolate clinical OC43-Paris;
RX PubMed=15280490; DOI=10.1128/jvi.78.16.8824-8834.2004;
RA St Jean J.R., Jacomy H., Desforges M., Vabret A., Freymuth F., Talbot P.J.;
RT "Human respiratory coronavirus OC43: genetic stability and neuroinvasion.";
RL J. Virol. 78:8824-8834(2004).
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:7844564}.
CC -!- SIMILARITY: Belongs to the coronaviruses ns2a protein family.
CC {ECO:0000305}.
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DR EMBL; L37833; AAA74377.1; -; mRNA.
DR EMBL; AY391777; AAR01013.1; -; Genomic_RNA.
DR EMBL; AY903459; AAX85667.1; -; Genomic_RNA.
DR EMBL; AY903460; AAX85676.1; -; Genomic_RNA.
DR EMBL; AY585228; AAT84352.1; -; Genomic_RNA.
DR EMBL; AY585229; AAT84360.1; -; Genomic_RNA.
DR SMR; Q80872; -.
DR Proteomes; UP000007552; Genome.
DR Proteomes; UP000100580; Genome.
DR Proteomes; UP000159995; Genome.
DR Proteomes; UP000161137; Genome.
DR Proteomes; UP000180344; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR007878; Coronavirus_NS2A.
DR InterPro; IPR039573; NS2A-like.
DR Pfam; PF05213; Corona_NS2A; 1.
DR PIRSF; PIRSF003890; LigT_coronavirus; 1.
PE 2: Evidence at transcript level;
KW Host cytoplasm.
FT CHAIN 1..278
FT /note="Non-structural protein 2a"
FT /id="PRO_0000106067"
FT VARIANT 274
FT /note="P -> S (in strain: Isolate ATCC VR-759, Isolate
FT clinical OC43-Paris, Isolate 19572 Belgium 2004 and Isolate
FT 87309 Belgium 2003)"
FT VARIANT 278
FT /note="D -> Y (in strain: Isolate ATCC VR-759, Isolate
FT clinical OC43-Paris, Isolate 19572 Belgium 2004 and Isolate
FT 87309 Belgium 2003)"
SQ SEQUENCE 278 AA; 32216 MW; DE098BF595F57AE0 CRC64;
MAVAYADKPN HFINFPLTHF QGFVLNYKGL QFQILDEGVD CKIQTAPHIS LTMLDIQPED
YKSVDVAIQE VIDDMHWGDG FQIKFENPHI LGRCIVLDVK GVEELHDDLV NYIRDKGCVA
DQSRKWIGHC TIAQLTDAAL SIKENVDFIN SMQFNYKITI NPSSPARLEI VKLGAEKKDG
FYETIVSHWM GIRFEYTSPT DKLAMIMGYC CLDVVRKELE EGDLPENDDD AWFKLSYHYE
NNSWFFRHVY RKSFHFRKAC QNLDCNCLGF YESPVEED
