NS2_HRSVB
ID NS2_HRSVB Reviewed; 124 AA.
AC O42038;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 23-FEB-2022, entry version 63.
DE RecName: Full=Non-structural protein 2;
DE Short=NS2;
DE AltName: Full=Non-structural protein 1B;
GN Name=1B; Synonyms=NS2;
OS Human respiratory syncytial virus B (strain B1).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.
OX NCBI_TaxID=79692;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E.,
RA Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R.,
RA Sidhu M.S.;
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP REVIEW.
RX PubMed=31622448; DOI=10.1371/journal.ppat.1007984;
RA Sedeyn K., Schepens B., Saelens X.;
RT "Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional
RT disrupters of innate immune responses.";
RL PLoS Pathog. 15:e1007984-e1007984(2019).
RN [3]
RP REVIEW.
RX PubMed=32509597; DOI=10.3389/fcimb.2020.00225;
RA Thornhill E.M., Verhoeven D.;
RT "Respiratory Syncytial Virus's Non-structural Proteins: Masters of
RT Interference.";
RL Front. Cell. Infect. Microbiol. 10:225-225(2020).
CC -!- FUNCTION: Plays a major role in antagonizing the type I IFN-mediated
CC antiviral response. Acts cooperatively with NS1 to repress activation
CC and nuclear translocation of host IFN-regulatory factor IRF3. Interacts
CC with the host cytoplasmic sensor of viral nucleic acids DDX58/RIG-I and
CC prevents the interaction with its downstream partner MAVS. Together
CC with NS2, participates in the proteasomal degradation of host STAT2,
CC IRF3, IRF7, TBK1 and DDX58 through a NS-degradasome involving CUL2 and
CC Elongin-C. The degradasome requires an intact mitochondrial MAVS.
CC Induces host SOCS1 expression. Induces activation of NF-kappa-B.
CC Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-
CC independent mechanism promoting continued viral replication.
CC {ECO:0000250|UniProtKB:P04543}.
CC -!- SUBUNIT: Monomer (instable). Homomultimer. Heteromultimer with NS1.
CC Interacts with host DDX58 (via N-terminus); this interaction prevents
CC host signaling pathway involved in interferon production. Interacts
CC with host MAP1B/microtubule-associated protein 1B.
CC {ECO:0000250|UniProtKB:P04543}.
CC -!- SUBCELLULAR LOCATION: Host mitochondrion
CC {ECO:0000250|UniProtKB:P04543}. Note=Most NS2 resides in the
CC mitochondria as a heteromer with NS1. {ECO:0000250|UniProtKB:P04543}.
CC -!- DOMAIN: The DNLP motif has IFN suppressive functions like binding to
CC host MAP1B. {ECO:0000250|UniProtKB:P04543}.
CC -!- SIMILARITY: Belongs to the pneumovirus non-structural protein 2 family.
CC {ECO:0000305}.
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DR EMBL; AF013254; AAB82430.1; -; Genomic_RNA.
DR EMBL; AF013255; AAB82441.1; -; Genomic_RNA.
DR RefSeq; NP_056857.1; NC_001781.1.
DR SMR; O42038; -.
DR PRIDE; O42038; -.
DR GeneID; 1489819; -.
DR KEGG; vg:1489819; -.
DR Proteomes; UP000002472; Genome.
DR Proteomes; UP000180717; Genome.
DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
DR GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR InterPro; IPR004336; RSV_NS2.
DR Pfam; PF03113; RSV_NS2; 1.
PE 3: Inferred from homology;
KW Host mitochondrion; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Inhibition of host IRF3 by virus; Inhibition of host IRF7 by virus;
KW Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW Inhibition of host STAT2 by virus; Inhibition of host TBK1 by virus;
KW Inhibition of host TLR pathway by virus;
KW Interferon antiviral system evasion;
KW Modulation of host cell apoptosis by virus; Reference proteome;
KW Viral immunoevasion.
FT CHAIN 1..124
FT /note="Non-structural protein 2"
FT /id="PRO_0000142790"
FT MOTIF 121..124
FT /note="DLNP; interaction with MAP1B"
FT /evidence="ECO:0000250|UniProtKB:P04543"
SQ SEQUENCE 124 AA; 14567 MW; A9FD37D964F97073 CRC64;
MSTTNDNTTM QRLMITDMRP LSMDSIITSL TKEIITHKFI YLINNECIVR KLDERQATFT
FLVNYEMKLL HKVGSTKYKK YTEYNTKYGT FPMPIFINHG GFLECIGIKP TKHTPIIYKY
DLNP
