ID   NS2_MPV15               Reviewed;         156 AA.
AC   P28889; Q5MKM9;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   23-FEB-2022, entry version 76.
DE   RecName: Full=Non-structural protein 2;
DE            Short=NS2;
DE   AltName: Full=Non-structural protein 1B;
GN   Name=1B; Synonyms=NS2;
OS   Murine pneumonia virus (strain 15) (MPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.
OX   NCBI_TaxID=296738;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1919530; DOI=10.1099/0022-1317-72-10-2545;
RA   Chambers P., Pringle C.R., Easton A.J.;
RT   "Genes 1 and 2 of pneumonia virus of mice encode proteins which have little
RT   homology with the 1C and 1B proteins of human respiratory syncytial
RT   virus.";
RL   J. Gen. Virol. 72:2545-2549(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15604443; DOI=10.1099/vir.0.80315-0;
RA   Thorpe L.C., Easton A.J.;
RT   "Genome sequence of the non-pathogenic strain 15 of pneumonia virus of mice
RT   and comparison with the genome of the pathogenic strain J3666.";
RL   J. Gen. Virol. 86:159-169(2005).
CC   -!- FUNCTION: Plays a major role in antagonizing the type I IFN-mediated
CC       antiviral response. May also inhibit viral transcription and RNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pneumovirus non-structural protein 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AY743910; AAW02833.1; -; Genomic_RNA.
DR   PIR; JQ1256; MNNZ2G.
DR   Proteomes; UP000133604; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039540; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Apoptosis; Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host RIG-I by virus; Inhibition of host RLR pathway by virus;
KW   Interferon antiviral system evasion; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..156
FT                   /note="Non-structural protein 2"
FT                   /id="PRO_0000142808"
SQ   SEQUENCE   156 AA;  18233 MW;  4A42D4DACEE91060 CRC64;
     MSTAMNKFTQ TISKPATILN ISDSEESGDE AGVGKVSRTT QSSERWLDLL IEKFQPSLQN
     ITRYINWNFI RICNDRLKKE KMGYIEAKQY VEDMAWMVIA SEADSIEWKC IRRQEKVTGV
     KYPKFFFVQH KEDWIECTGC IPYPGHDLIY DEDDDD