ID   NS3A_IBVB               Reviewed;          57 AA.
AC   P30237; Q89429;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Non-structural protein 3a;
DE            Short=ns3a;
DE   AltName: Full=Accessory protein 3a;
DE   Flags: Precursor;
GN   ORFNames=3a;
OS   Avian infectious bronchitis virus (strain Beaudette) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=11122;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2829563; DOI=10.1007/978-1-4684-1280-2_6;
RA   Smith A.R., Boursnell M.E.G., Binns M.M., Brown T.D.K., Inglis S.C.;
RT   "Identification of a new gene product encoded by mRNA D of infectious
RT   bronchitis virus.";
RL   Adv. Exp. Med. Biol. 218:47-54(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1653486; DOI=10.1016/0042-6822(91)90423-9;
RA   Liu D.X., Cavanagh D., Green P., Inglis S.C.;
RT   "A polycistronic mRNA specified by the coronavirus infectious bronchitis
RT   virus.";
RL   Virology 184:531-544(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2995560; DOI=10.1099/0022-1317-66-10-2253;
RA   Boursnell M.E.G., Binns M.M., Brown T.D.K.;
RT   "Sequencing of coronavirus IBV genomic RNA: three open reading frames in
RT   the 5' 'unique' region of mRNA D.";
RL   J. Gen. Virol. 66:2253-2258(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3027249; DOI=10.1099/0022-1317-68-1-57;
RA   Boursnell M.E.G., Brown T.D.K., Foulds I.J., Green P.F., Tomley F.M.,
RA   Binns M.M.;
RT   "Completion of the sequence of the genome of the coronavirus avian
RT   infectious bronchitis virus.";
RL   J. Gen. Virol. 68:57-77(1987).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15661153; DOI=10.1016/j.virol.2004.10.045;
RA   Youn S., Leibowitz J.L., Collisson E.W.;
RT   "In vitro assembled, recombinant infectious bronchitis viruses demonstrate
RT   that the 5a open reading frame is not essential for replication.";
RL   Virology 332:206-215(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate IBV-EP3, and Isolate Vero cell-adapted p65;
RX   PubMed=16137658; DOI=10.1016/j.bbrc.2005.08.105;
RA   Fang S.G., Shen S., Tay F.P., Liu D.X.;
RT   "Selection of and recombination between minor variants lead to the
RT   adaptation of an avian coronavirus to primate cells.";
RL   Biochem. Biophys. Res. Commun. 336:417-423(2005).
RN   [7]
RP   FUNCTION.
RX   PubMed=26401035; DOI=10.1128/jvi.01057-15;
RA   Kint J., Dickhout A., Kutter J., Maier H.J., Britton P., Koumans J.,
RA   Pijlman G.P., Fros J.J., Wiegertjes G.F., Forlenza M.;
RT   "Infectious Bronchitis Coronavirus Inhibits STAT1 Signaling and Requires
RT   Accessory Proteins for Resistance to Type I Interferon Activity.";
RL   J. Virol. 89:12047-12057(2015).
CC   -!- FUNCTION: Involved in resistance to IFN. {ECO:0000269|PubMed:26401035}.
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DR   EMBL; M27435; AAA46230.1; -; mRNA.
DR   EMBL; AY692454; AAV98209.1; -; mRNA.
DR   EMBL; M95169; AAA70236.1; -; Genomic_RNA.
DR   EMBL; DQ001338; AAY24424.1; -; Genomic_RNA.
DR   EMBL; DQ001339; AAY24434.1; -; Genomic_RNA.
DR   PIR; A41038; WMIHB1.
DR   RefSeq; NP_040832.1; NC_001451.1.
DR   SMR; P30237; -.
DR   GeneID; 1489742; -.
DR   Proteomes; UP000006717; Genome.
DR   Proteomes; UP000107149; Genome.
DR   InterPro; IPR005214; IBV_3A.
DR   Pfam; PF03617; IBV_3A; 1.
PE   3: Inferred from homology;
KW   Interferon antiviral system evasion; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..57
FT                   /note="Non-structural protein 3a"
FT                   /id="PRO_0000106108"
SQ   SEQUENCE   57 AA;  6668 MW;  55B167709D855C6A CRC64;
     MIQSPTSFLI VLILLWCKLV LSCFREFIIA LQQLIQVLLQ IINSNLQSRL TLWHSLD