ID   NS3B_BC133              Reviewed;         119 AA.
AC   P0C530;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Non-structural protein 3b;
DE            Short=ns3b;
DE   AltName: Full=Accessory protein 3b;
GN   ORFNames=3b;
OS   Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=389230;
OH   NCBI_TaxID=258959; Tylonycteris pachypus (Lesser bamboo bat) (Vespertilio pachypus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- FUNCTION: Induces host cell G0/G1 arrest and apoptosis.
CC       {ECO:0000250|UniProtKB:P59633}.
CC   -!- SUBUNIT: Interacts with host RUNX1 isoform b.
CC       {ECO:0000250|UniProtKB:P59633}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC       {ECO:0000250|UniProtKB:P59633}. Host mitochondrion
CC       {ECO:0000250|UniProtKB:P59633}.
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DR   EMBL; DQ648794; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0C530; -.
DR   Proteomes; UP000007449; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   InterPro; IPR014720; dsRBD_dom.
DR   Pfam; PF00035; dsrm; 1.
PE   3: Inferred from homology;
KW   Apoptosis; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW   Host mitochondrion; Host nucleus; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus;
KW   Modulation of host cell cycle by virus; Reference proteome; RNA-binding.
FT   CHAIN           1..119
FT                   /note="Non-structural protein 3b"
FT                   /id="PRO_0000290264"
FT   DOMAIN          2..83
FT                   /note="DRBM"
SQ   SEQUENCE   119 AA;  13898 MW;  CD1E1E9500F17976 CRC64;
     MDYVSLLNQF WQKQIKSYKE TPSQYHYLYP PRFFYKPVLG NLQHPTKWCC TIKFYEYSAQ
     ATECTKASAK QDAARLICEQ LQAAGLLNGM ELRFRSSASD IFGQNRYDAS KSYFFSKTA