NS3B_BCHK4
ID NS3B_BCHK4 Reviewed; 119 AA.
AC A3EX96;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 23-FEB-2022, entry version 60.
DE RecName: Full=Non-structural protein 3b;
DE Short=ns3b;
DE AltName: Full=Accessory protein 3b;
GN ORFNames=3b;
OS Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Merbecovirus.
OX NCBI_TaxID=694007;
OH NCBI_TaxID=258959; Tylonycteris pachypus (Lesser bamboo bat) (Vespertilio pachypus).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate HKU4-1;
RX PubMed=17121802; DOI=10.1128/jvi.02182-06;
RA Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L.,
RA Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H.,
RA Zheng B.-J., Yuen K.-Y.;
RT "Comparative analysis of twelve genomes of three novel group 2c and group
RT 2d coronaviruses reveals unique group and subgroup features.";
RL J. Virol. 81:1574-1585(2007).
CC -!- FUNCTION: Induces host cell G0/G1 arrest and apoptosis.
CC {ECO:0000250|UniProtKB:P59633}.
CC -!- SUBUNIT: Interacts with host RUNX1 isoform b.
CC {ECO:0000250|UniProtKB:P59633}.
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC {ECO:0000250|UniProtKB:P59633}. Host mitochondrion
CC {ECO:0000250|UniProtKB:P59633}.
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DR EMBL; EF065505; ABN10841.1; -; Genomic_RNA.
DR RefSeq; YP_001039955.1; NC_009019.1.
DR SMR; A3EX96; -.
DR GeneID; 4835992; -.
DR KEGG; vg:4835992; -.
DR Proteomes; UP000006574; Genome.
DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR InterPro; IPR014720; dsRBD_dom.
DR Pfam; PF00035; dsrm; 1.
PE 3: Inferred from homology;
KW Apoptosis; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW Host mitochondrion; Host nucleus; Host-virus interaction;
KW Modulation of host cell apoptosis by virus;
KW Modulation of host cell cycle by virus; Reference proteome; RNA-binding.
FT CHAIN 1..119
FT /note="Non-structural protein 3b"
FT /id="PRO_0000290265"
FT DOMAIN 2..83
FT /note="DRBM"
SQ SEQUENCE 119 AA; 13898 MW; CD1E1E9500F17976 CRC64;
MDYVSLLNQF WQKQIKSYKE TPSQYHYLYP PRFFYKPVLG NLQHPTKWCC TIKFYEYSAQ
ATECTKASAK QDAARLICEQ LQAAGLLNGM ELRFRSSASD IFGQNRYDAS KSYFFSKTA