ID   NS3B_BCHK5              Reviewed;         119 AA.
AC   A3EXD2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Non-structural protein 3b;
DE            Short=ns3b;
DE   AltName: Full=Accessory protein 3b;
GN   ORFNames=3b;
OS   Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=694008;
OH   NCBI_TaxID=105295; Pipistrellus abramus (Japanese pipistrelle) (Pipistrellus javanicus abramus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate HKU5-1;
RX   PubMed=17121802; DOI=10.1128/jvi.02182-06;
RA   Woo P.C.Y., Wang M., Lau S.K.P., Xu H.F., Poon R.W.S., Guo R., Wong B.H.L.,
RA   Gao K., Tsoi H.-W., Huang Y., Li K.S.M., Lam C.S.F., Chan K.-H.,
RA   Zheng B.-J., Yuen K.-Y.;
RT   "Comparative analysis of twelve genomes of three novel group 2c and group
RT   2d coronaviruses reveals unique group and subgroup features.";
RL   J. Virol. 81:1574-1585(2007).
CC   -!- FUNCTION: Induces host cell G0/G1 arrest and apoptosis.
CC       {ECO:0000250|UniProtKB:P59633}.
CC   -!- SUBUNIT: Interacts with host RUNX1 isoform b.
CC       {ECO:0000250|UniProtKB:P59633}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC       {ECO:0000250|UniProtKB:P59633}. Host mitochondrion
CC       {ECO:0000250|UniProtKB:P59633}.
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DR   EMBL; EF065509; ABN10877.1; -; Genomic_RNA.
DR   RefSeq; YP_001039964.1; NC_009020.1.
DR   SMR; A3EXD2; -.
DR   GeneID; 4836005; -.
DR   KEGG; vg:4836005; -.
DR   Proteomes; UP000007451; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Apoptosis; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW   Host mitochondrion; Host nucleus; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus;
KW   Modulation of host cell cycle by virus; Reference proteome; RNA-binding.
FT   CHAIN           1..119
FT                   /note="Non-structural protein 3b"
FT                   /id="PRO_0000290266"
FT   DOMAIN          3..79
FT                   /note="DRBM"
SQ   SEQUENCE   119 AA;  13688 MW;  98F2D33C64F645FA CRC64;
     MDYVSLLNQV WQKQVNSSQE GTLAPVRPTY AYRPVQGNLQ CPIKWRCIYT FAGYTGTATE
     PTKVLAKQEA ARKVCLRLQE YGRLDGFGLR LRYSTAFEHN RYDASKSYFY TQTSSSSHE