NS3B_SARS
ID NS3B_SARS Reviewed; 154 AA.
AC P59633; Q7TFA9; Q80BV4;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=ORF3b protein;
DE AltName: Full=Accessory protein 3b;
DE AltName: Full=Non-structural protein 3b;
DE Short=ns3b;
DE AltName: Full=Protein X2;
GN ORFNames=3b;
OS Severe acute respiratory syndrome coronavirus (SARS-CoV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Sarbecovirus.
OX NCBI_TaxID=694009;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Urbani;
RX PubMed=12730500; DOI=10.1126/science.1085952;
RA Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
RA Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S.,
RA Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D.,
RA Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S.,
RA Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R.,
RA Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J.,
RA Bellini W.J.;
RT "Characterization of a novel coronavirus associated with severe acute
RT respiratory syndrome.";
RL Science 300:1394-1399(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Tor2;
RX PubMed=12730501; DOI=10.1126/science.1085953;
RA Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
RA Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
RA Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R.,
RA Mayo M., McDonald H., Montgomery S.B., Pandoh P.K., Petrescu A.S.,
RA Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M.,
RA Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K.,
RA Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R.,
RA Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A.,
RA Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S.,
RA Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M.,
RA Skowronski D.M., Upton C., Roper R.L.;
RT "The genome sequence of the SARS-associated coronavirus.";
RL Science 300:1399-1404(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate CUHK-Su10, and Isolate CUHK-W1;
RX PubMed=12853594; DOI=10.1056/nejm200307103490216;
RA Tsui S.K.W., Chim S.S.C., Lo Y.M.D.;
RT "Coronavirus genomic-sequence variations and the epidemiology of the severe
RT acute respiratory syndrome.";
RL N. Engl. J. Med. 349:187-188(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate HKU-39849;
RX PubMed=12876307; DOI=10.1177/15353702-0322807-13;
RA Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C.,
RA Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B.,
RA Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.;
RT "The complete genome sequence of severe acute respiratory syndrome
RT coronavirus strain HKU-39849 (HK-39).";
RL Exp. Biol. Med. 228:866-873(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, and
RC Isolate GD01;
RA Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W., Jiang T.,
RA Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y., Li X., Lu F.,
RA Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L., Deng Y., Dong W.,
RA Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H., Li S., Li S., Li W.,
RA Li W., Lin W., Liu J., Liu Z., Lu H., Ni P., Qi Q., Sun Y., Tang L.,
RA Tong Z., Wang J., Wang X., Wu Q., Xi Y., Xu Z., Yang L., Ye C., Ye J.,
RA Zhang B., Zhang F., Zhang J., Zhang X., Zhou J., Yang H.;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate TW1;
RA Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.;
RT "The complete genome of SARS coronavirus clone TW1.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate FRA;
RA Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S.,
RA Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J.,
RA Song H.C., Abrignani S., Covacci A., Rappuoli R.;
RT "SARS virus is a close relative of type II coronaviruses.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Frankfurt 1;
RA Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S.,
RA Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Shanghai QXC1;
RA Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.;
RT "Analysis of SARS coronavirus genome in Shanghai isolates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Taiwan TC1, Isolate Taiwan TC2, and Isolate Taiwan TC3;
RA Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L., Shih M.-C.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, and Isolate TWY;
RA Shu H.Y., Wu K.M., Tsai S.F.;
RT "The complete genome of SARS coronavirus TWH.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate HSR 1;
RA Canducci F., Clementi M., Poli G., Vicenzi E.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [13]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate AS;
RA Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M.,
RA Ruan Y.J., Salemi M.;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [14]
RP FUNCTION.
RX PubMed=16107218; DOI=10.1186/1743-422x-2-66;
RA Yuan X., Shan Y., Zhao Z., Chen J., Cong Y.;
RT "G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected
RT cells.";
RL Virol. J. 2:66-66(2005).
RN [15]
RP SUBCELLULAR LOCATION.
RX PubMed=16046244; DOI=10.1016/j.virusres.2005.06.001;
RA Yuan X., Yao Z., Shan Y., Chen B., Yang Z., Wu J., Zhao Z., Chen J.,
RA Cong Y.;
RT "Nucleolar localization of non-structural protein 3b, a protein
RT specifically encoded by the severe acute respiratory syndrome
RT coronavirus.";
RL Virus Res. 114:70-79(2005).
RN [16]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16682811;
RA Yuan X., Shan Y., Yao Z., Li J., Zhao Z., Chen J., Cong Y.;
RT "Mitochondrial location of severe acute respiratory syndrome coronavirus 3b
RT protein.";
RL Mol. Cells 21:186-191(2006).
RN [17]
RP INTERACTION WITH HOST RUNX1.
RX PubMed=22253733; DOI=10.1371/journal.pone.0029542;
RA Varshney B., Agnihothram S., Agnihotram S., Tan Y.J., Baric R., Lal S.K.;
RT "SARS coronavirus 3b accessory protein modulates transcriptional activity
RT of RUNX1b.";
RL PLoS ONE 7:E29542-E29542(2012).
CC -!- FUNCTION: Induces host cell G0/G1 arrest and apoptosis.
CC {ECO:0000269|PubMed:16107218, ECO:0000269|PubMed:16682811}.
CC -!- SUBUNIT: Interacts with host RUNX1 isoform b.
CC {ECO:0000269|PubMed:22253733}.
CC -!- INTERACTION:
CC P59633; Q01196-1: RUNX1; Xeno; NbExp=6; IntAct=EBI-25489004, EBI-925940;
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC {ECO:0000269|PubMed:16046244}. Host mitochondrion
CC {ECO:0000269|PubMed:16682811}.
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DR EMBL; AY278741; AAP13447.1; -; Genomic_RNA.
DR EMBL; AY274119; AAP41039.1; -; Genomic_RNA.
DR EMBL; AY282752; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY278554; AAP13569.1; -; Genomic_RNA.
DR EMBL; AY278491; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY278487; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY278488; AAP30032.1; -; Genomic_RNA.
DR EMBL; AY278489; AAP51229.1; -; Genomic_RNA.
DR EMBL; AY278490; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY279354; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR EMBL; AY291451; AAP37019.1; -; Genomic_RNA.
DR EMBL; AY310120; AAP50487.1; -; Genomic_RNA.
DR EMBL; AY291315; AAP33699.1; -; Genomic_RNA.
DR EMBL; AY463059; AAR86789.1; -; Genomic_RNA.
DR EMBL; AY338174; AAQ01599.1; -; Genomic_RNA.
DR EMBL; AY338175; AAQ01611.1; -; Genomic_RNA.
DR EMBL; AY348314; AAP97884.1; -; Genomic_RNA.
DR EMBL; AP006557; BAC81350.1; -; Genomic_RNA.
DR EMBL; AP006558; BAC81364.1; -; Genomic_RNA.
DR EMBL; AP006559; BAC81378.1; -; Genomic_RNA.
DR EMBL; AP006560; BAC81392.1; -; Genomic_RNA.
DR EMBL; AP006561; BAC81406.1; -; Genomic_RNA.
DR EMBL; AY323977; AAP72976.1; -; Genomic_RNA.
DR EMBL; AY427439; AAQ94062.1; -; Genomic_RNA.
DR RefSeq; NP_828853.1; NC_004718.3.
DR SMR; P59633; -.
DR BioGRID; 4383918; 121.
DR IntAct; P59633; 115.
DR MINT; P59633; -.
DR GeneID; 1489670; -.
DR SIGNOR; P59633; -.
DR Proteomes; UP000000354; Genome.
DR Proteomes; UP000103670; Genome.
DR Proteomes; UP000109640; Genome.
DR Proteomes; UP000116947; Genome.
DR Proteomes; UP000121636; Genome.
DR Proteomes; UP000131569; Genome.
DR Proteomes; UP000131955; Genome.
DR Proteomes; UP000137377; Genome.
DR Proteomes; UP000138690; Genome.
DR Proteomes; UP000143093; Genome.
DR Proteomes; UP000145651; Genome.
DR Proteomes; UP000146108; Genome.
DR Proteomes; UP000146181; Genome.
DR Proteomes; UP000146296; Genome.
DR Proteomes; UP000148194; Genome.
DR Proteomes; UP000153467; Genome.
DR Proteomes; UP000160648; Genome.
DR Proteomes; UP000164441; Genome.
DR Proteomes; UP000172416; Genome.
DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR GO; GO:0001817; P:regulation of cytokine production; IEP:CACAO.
DR CDD; cd21649; SARS-CoV_ORF3b; 1.
DR InterPro; IPR022117; SARS_3b.
DR Pfam; PF12383; SARS_3b; 1.
PE 1: Evidence at protein level;
KW Apoptosis; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW Host mitochondrion; Host nucleus; Host-virus interaction;
KW Modulation of host cell apoptosis by virus;
KW Modulation of host cell cycle by virus; Reference proteome.
FT CHAIN 1..154
FT /note="ORF3b protein"
FT /id="PRO_0000106132"
FT REGION 80..138
FT /note="Mitochondrial targeting signal"
FT REGION 134..154
FT /note="Nucleolar targeting"
FT MOTIF 135..153
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT VARIANT 31
FT /note="K -> Q (in strain: Isolate GD01)"
FT VARIANT 99
FT /note="T -> I (in strain: Isolate BJ02)"
FT VARIANT 115
FT /note="L -> Q (in strain: Isolate GD01)"
FT VARIANT 121
FT /note="Q -> P (in strain: Isolate BJ01 and Isolate BJ04)"
SQ SEQUENCE 154 AA; 17750 MW; 82AB0B68F11060A8 CRC64;
MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL RIGTQVLKTM
SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH RMCKYTQSTA LQELLIQQWI
QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK KQVR