ID   NS3D_BC133              Reviewed;         227 AA.
AC   Q0Q4E9;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Non-structural protein 3d;
DE            Short=ns3d;
DE   AltName: Full=Accessory protein 3d;
GN   ORFNames=3d;
OS   Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=389230;
OH   NCBI_TaxID=258959; Tylonycteris pachypus (Lesser bamboo bat) (Vespertilio pachypus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; DQ648794; ABG47055.1; -; Genomic_RNA.
DR   Proteomes; UP000007449; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd21645; MERS-CoV-like_ORF5; 1.
DR   InterPro; IPR044323; MERS-CoV-like_ORF5.
DR   PROSITE; PS51967; COV_VIROPORIN_3A_CD; 1.
DR   PROSITE; PS51966; COV_VIROPORIN_3A_TM; 1.
PE   4: Predicted;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..227
FT                   /note="Non-structural protein 3d"
FT                   /id="PRO_0000290270"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          27..130
FT                   /note="CoV 3a-like viroporin TM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01311"
FT   DOMAIN          134..191
FT                   /note="CoV 3a-like viroporin CD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01312"
SQ   SEQUENCE   227 AA;  25399 MW;  9EE7E3F66C38D958 CRC64;
     MAFSASLFRT KTVHTEDALC PRSAIQAEQP PNIIDCIPVA GYEAALVTNA LFLLVLFVFN
     PLTCKGNWIK AILFYSLLLY NMILAIFLVI DTQHFVSALL LAYVVTFLIL WTADRVRLSC
     AVGSVLPFVD MRSSYIRVDN GNSSVVVPMN HTKHWFIRNF EQSCHCENCF YIHSSSYVEC
     TFISRLKKSI LVSVCDFSLG GNVSTVFVPS SDKTVPLHII APSKLYV