ID   NS3_BC512               Reviewed;         224 AA.
AC   Q0Q465;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Non-structural protein 3;
DE            Short=ns3;
DE   AltName: Full=Accessory protein 3a;
GN   ORFNames=3;
OS   Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Pedacovirus.
OX   NCBI_TaxID=693999;
OH   NCBI_TaxID=153297; Scotophilus kuhlii (Lesser asiatic yellow bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Bat coronavirus 512/2005 is highly similar to porcine
CC       epidemic diarrhea virus (PEDV).
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DR   EMBL; DQ648858; ABG47079.1; -; Genomic_RNA.
DR   RefSeq; YP_001351685.1; NC_009657.1.
DR   GeneID; 11266519; -.
DR   KEGG; vg:11266519; -.
DR   Proteomes; UP000113079; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004293; Coronavirus_Orf3b.
DR   Pfam; PF03053; Corona_NS3b; 1.
DR   PROSITE; PS51967; COV_VIROPORIN_3A_CD; 1.
DR   PROSITE; PS51966; COV_VIROPORIN_3A_TM; 1.
PE   4: Predicted;
KW   Host membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..224
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000289889"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..124
FT                   /note="CoV 3a-like viroporin TM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01311"
FT   DOMAIN          128..203
FT                   /note="CoV 3a-like viroporin CD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01312"
SQ   SEQUENCE   224 AA;  25573 MW;  2E67484D1E465CC4 CRC64;
     MFLGLFQYTI DTAVEHTVEH ANLSQEEALM LEENIVPLRQ ATHVTGFLLT SVFVYFFALF
     KASSYKRNLL LFLARLLALL IYAPILIFCG AYLDAFIVVA TLTSRLLFLT YYSWRYKTYK
     FLIYNSSTLM FLHGHANYYN GRPYVMLEGG SHYVTLGTDI VPFVSRSNLY LAIRGSAESD
     IQLLRTVELL DGNYLYIFSS CQVVGVTNSG FEEIQLDEYA TISE