ID   NS4_BTVBZ               Reviewed;          77 AA.
AC   P0DJZ7;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   09-DEC-2015, sequence version 1.
DT   23-FEB-2022, entry version 9.
DE   RecName: Full=Protein NS4;
GN   Name=Segment-9;
OS   Bluetongue virus 13 (isolate 13B89Z) (BTV 13).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=355314;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=13B89Z;
RX   PubMed=8764098; DOI=10.1128/jvi.70.8.5735-5739.1996;
RA   de Mattos C.C., de Mattos C.A., MacLachlan N.J., Giavedoni L.D., Yilma T.,
RA   Osburn B.I.;
RT   "Phylogenetic comparison of the S3 gene of United States prototype strains
RT   of bluetongue virus with that of field isolates from California.";
RL   J. Virol. 70:5735-5739(1996).
RN   [2]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX   PubMed=22022432; DOI=10.1371/journal.pone.0025697;
RA   Belhouchet M., Mohd Jaafar F., Firth A.E., Grimes J.M., Mertens P.P.,
RA   Attoui H.;
RT   "Detection of a fourth orbivirus non-structural protein.";
RL   PLoS ONE 6:E25697-E25697(2011).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22241985; DOI=10.1371/journal.ppat.1002477;
RA   Ratinier M., Caporale M., Golder M., Franzoni G., Allan K., Nunes S.F.,
RA   Armezzani A., Bayoumy A., Rixon F., Shaw A., Palmarini M.;
RT   "Identification and characterization of a novel non-structural protein of
RT   bluetongue virus.";
RL   PLoS Pathog. 7:E1002477-E1002477(2011).
CC   -!- FUNCTION: May function as a nucleic acid binding protein that modulates
CC       transcription of genes participating in the IFN response.
CC       {ECO:0000269|PubMed:22241985}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:22022432}.
CC       Host nucleus {ECO:0000269|PubMed:22022432}. Host nucleus, host
CC       nucleolus {ECO:0000269|PubMed:22241985}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Protein NS4;
CC         IsoId=P0DJZ7-1; Sequence=Displayed;
CC       Name=Protein VP6;
CC         IsoId=P0C6L1-1; Sequence=External;
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DR   EMBL; U55791; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Alternative initiation; Host cytoplasm; Host nucleus.
FT   CHAIN           1..77
FT                   /note="Protein NS4"
FT                   /id="PRO_0000434884"
SQ   SEQUENCE   77 AA;  9511 MW;  1050971B3524FD7C CRC64;
     MVRGRNRRAA RRKRAAKRLK MQMWIDAYIL QWDLDQAQKD LENARTRMLT EEMERLEEEV
     EMLMRELELL ERMEEDG