ID   NS4_CVMS                Reviewed;         124 AA.
AC   P29075;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 52.
DE   RecName: Full=Non-structural protein 4;
DE            Short=ns4;
DE   AltName: Full=Accessory protein 4;
GN   ORFNames=4;
OS   Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=11145;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1654456; DOI=10.1128/jvi.65.10.5605-5608.1991;
RA   Yokomori K., Lai M.M.C.;
RT   "Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins
RT   ns4 and ns5a are not essential for murine coronavirus replication.";
RL   J. Virol. 65:5605-5608(1991).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the coronaviruses ns4/ns4.8 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M64835; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; A40512; MNIHMS.
DR   SMR; P29075; -.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005603; Corona_NS4.
DR   Pfam; PF03905; Corona_NS4; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..124
FT                   /note="Non-structural protein 4"
FT                   /id="PRO_0000106069"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  13335 MW;  A16B051237EE4807 CRC64;
     MAVLGPKATL AAVFIGPFIV ACMLGIGLVY LLQLQVQIFH VKDTIRVTGK PATVSYTIST
     PVTPSATTLD GTTYTLIRPT SSYTRVYLGK TRGFDTSTFG PKVLDYITSS KPHLNSGRPY
     SLSC