ID   NS5A_IBVB               Reviewed;          65 AA.
AC   Q89613; Q5MNY7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Non-structural protein 5a;
DE            Short=ns5a;
DE   AltName: Full=Accessory protein 5a;
GN   ORFNames=5a;
OS   Avian infectious bronchitis virus (strain Beaudette) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=11122;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6092234; DOI=10.1016/0378-1119(84)90169-0;
RA   Boursnell M.E.G., Brown T.D.K.;
RT   "Sequencing of coronavirus IBV genomic RNA: a 195-base open reading frame
RT   encoded by mRNA B.";
RL   Gene 29:87-92(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3027249; DOI=10.1099/0022-1317-68-1-57;
RA   Boursnell M.E.G., Brown T.D.K., Foulds I.J., Green P.F., Tomley F.M.,
RA   Binns M.M.;
RT   "Completion of the sequence of the genome of the coronavirus avian
RT   infectious bronchitis virus.";
RL   J. Gen. Virol. 68:57-77(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6331112; DOI=10.1007/978-1-4615-9373-7_21;
RA   Boursnell M.E.G., Brown T.D.K.;
RT   "DNA sequencing studies of genomic cDNA clones of avian infectious
RT   bronchitis virus.";
RL   Adv. Exp. Med. Biol. 173:215-224(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Isolate Vero cell-adapted;
RX   PubMed=15661153; DOI=10.1016/j.virol.2004.10.045;
RA   Youn S., Leibowitz J.L., Collisson E.W.;
RT   "In vitro assembled, recombinant infectious bronchitis viruses demonstrate
RT   that the 5a open reading frame is not essential for replication.";
RL   Virology 332:206-215(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate IBV-EP3, and Isolate Vero cell-adapted p65;
RX   PubMed=16137658; DOI=10.1016/j.bbrc.2005.08.105;
RA   Fang S.G., Shen S., Tay F.P., Liu D.X.;
RT   "Selection of and recombination between minor variants lead to the
RT   adaptation of an avian coronavirus to primate cells.";
RL   Biochem. Biophys. Res. Commun. 336:417-423(2005).
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DR   EMBL; M95169; AAA70240.1; -; Genomic_RNA.
DR   EMBL; M25905; AAA46218.1; -; Genomic_RNA.
DR   EMBL; AY692454; AAV98211.1; -; mRNA.
DR   EMBL; DQ001338; AAY24428.1; -; Genomic_RNA.
DR   EMBL; DQ001339; AAY24438.1; -; Genomic_RNA.
DR   RefSeq; NP_040836.1; NC_001451.1.
DR   GeneID; 1489744; -.
DR   Proteomes; UP000006717; Genome.
DR   Proteomes; UP000107149; Genome.
DR   InterPro; IPR009404; Corona_5a.
DR   Pfam; PF06336; Corona_5a; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..65
FT                   /note="Non-structural protein 5a"
FT                   /id="PRO_0000289890"
FT   VARIANT         6
FT                   /note="S -> I (in strain: Isolate IBV-EP3, Isolate Vero
FT                   cell-adapted and Isolate Vero cell-adapted p65)"
SQ   SEQUENCE   65 AA;  7505 MW;  BD94A6A1E105E56D CRC64;
     MKWLTSFGRA VISCYKSLLL TQLRVLDRLI LDHGLLRVLT CSRRVLLVQL DLVYRLAYTP
     TQSLA