NS5B_IBVB
ID NS5B_IBVB Reviewed; 82 AA.
AC Q89786; Q4ZJS5; Q4ZJT6; Q5MNY6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Host translation inhibitor 5b;
DE Short=ns5b;
DE AltName: Full=Accessory protein 5b;
GN ORFNames=5b;
OS Avian infectious bronchitis virus (strain Beaudette) (IBV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Gammacoronavirus; Igacovirus.
OX NCBI_TaxID=11122;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=6092234; DOI=10.1016/0378-1119(84)90169-0;
RA Boursnell M.E.G., Brown T.D.K.;
RT "Sequencing of coronavirus IBV genomic RNA: a 195-base open reading frame
RT encoded by mRNA B.";
RL Gene 29:87-92(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3027249; DOI=10.1099/0022-1317-68-1-57;
RA Boursnell M.E.G., Brown T.D.K., Foulds I.J., Green P.F., Tomley F.M.,
RA Binns M.M.;
RT "Completion of the sequence of the genome of the coronavirus avian
RT infectious bronchitis virus.";
RL J. Gen. Virol. 68:57-77(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=6331112; DOI=10.1007/978-1-4615-9373-7_21;
RA Boursnell M.E.G., Brown T.D.K.;
RT "DNA sequencing studies of genomic cDNA clones of avian infectious
RT bronchitis virus.";
RL Adv. Exp. Med. Biol. 173:215-224(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Isolate Vero cell-adapted;
RX PubMed=15661153; DOI=10.1016/j.virol.2004.10.045;
RA Youn S., Leibowitz J.L., Collisson E.W.;
RT "In vitro assembled, recombinant infectious bronchitis viruses demonstrate
RT that the 5a open reading frame is not essential for replication.";
RL Virology 332:206-215(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate IBV-EP3, and Isolate Vero cell-adapted p65;
RX PubMed=16137658; DOI=10.1016/j.bbrc.2005.08.105;
RA Fang S.G., Shen S., Tay F.P., Liu D.X.;
RT "Selection of and recombination between minor variants lead to the
RT adaptation of an avian coronavirus to primate cells.";
RL Biochem. Biophys. Res. Commun. 336:417-423(2005).
CC -!- FUNCTION: Involved in host translation shutoff without degradating host
CC RNA. By suppressing host gene expression, facilitates the evasion from
CC host type I interferon immune response. {ECO:0000250|UniProtKB:Q80RZ3}.
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DR EMBL; M95169; AAA70241.1; -; Genomic_RNA.
DR EMBL; M25905; AAA46219.1; -; Genomic_RNA.
DR EMBL; AY692454; AAV98212.1; -; mRNA.
DR EMBL; DQ001338; AAY24429.1; -; Genomic_RNA.
DR EMBL; DQ001339; AAY24439.1; -; Genomic_RNA.
DR RefSeq; NP_040837.1; NC_001451.1.
DR GeneID; 1489744; -.
DR KEGG; vg:1489744; -.
DR Proteomes; UP000006717; Genome.
DR Proteomes; UP000107149; Genome.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR InterPro; IPR008458; Acc_prot_5b_avian_CoV.
DR Pfam; PF05528; Coronavirus_5; 1.
PE 3: Inferred from homology;
KW Eukaryotic host gene expression shutoff by virus;
KW Host gene expression shutoff by virus; Host-virus interaction;
KW Interferon antiviral system evasion; Reference proteome.
FT CHAIN 1..82
FT /note="Host translation inhibitor 5b"
FT /id="PRO_0000289891"
FT VARIANT 36
FT /note="Q -> R (in strain: Isolate Vero cell-adapted)"
FT VARIANT 72
FT /note="E -> G (in strain: Isolate IBV-EP3, Isolate Vero
FT cell-adapted and Isolate Vero cell-adapted p65)"
FT VARIANT 73
FT /note="K -> R (in strain: Isolate Vero cell-adapted)"
FT VARIANT 81
FT /note="L -> S (in strain: Isolate Vero cell-adapted and
FT Isolate Vero cell-adapted p65)"
SQ SEQUENCE 82 AA; 9334 MW; 3FB772DD895DE33B CRC64;
MNNSKDNPFR GAIARKARIY LREGLDCVYF LNKAGQAEPC PACTSLVFQG KTCEEHIHNN
NLLSWQAVKQ LEKQTPQRQS LN
