ID   NS5B_IBVK               Reviewed;          82 AA.
AC   P19745;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Host translation inhibitor 5b;
DE            Short=ns5b;
DE   AltName: Full=Accessory protein 5b;
GN   ORFNames=5b;
OS   Avian infectious bronchitis virus (strain KB8523) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=11126;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2841803; DOI=10.1016/0042-6822(88)90603-4;
RA   Sutou S., Sato S., Okabe T., Nakai M., Sasaki N.;
RT   "Cloning and sequencing of genes encoding structural proteins of avian
RT   infectious bronchitis virus.";
RL   Virology 165:589-595(1988).
CC   -!- FUNCTION: Involved in host translation shutoff without degradating host
CC       RNA. By suppressing host gene expression, facilitates the evasion from
CC       host type I interferon immune response. {ECO:0000250|UniProtKB:Q80RZ3}.
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DR   EMBL; M21515; AAA66582.1; -; Genomic_RNA.
DR   PIR; F29249; QQIHI2.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR008458; Acc_prot_5b_avian_CoV.
DR   Pfam; PF05528; Coronavirus_5; 1.
PE   3: Inferred from homology;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Interferon antiviral system evasion.
FT   CHAIN           1..82
FT                   /note="Host translation inhibitor 5b"
FT                   /id="PRO_0000106125"
SQ   SEQUENCE   82 AA;  9392 MW;  E8EADFDD8942DE29 CRC64;
     MNNSKDNPFR GAIARKARIY LREGLDCVYF LNKAGQAEPC PACTSLVFQG KTCEEHIHNN
     NLLSWQVVRQ LERQTPQRQS SN