ID   NS5B_IBVM               Reviewed;          82 AA.
AC   Q80RZ3; Q5I5X3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Host translation inhibitor 5b;
DE            Short=ns5b;
DE   AltName: Full=Accessory protein 5b;
GN   ORFNames=5b;
OS   Avian infectious bronchitis virus (strain M41) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=11127;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15019237; DOI=10.1016/j.virusres.2003.11.016;
RA   Brooks J.E., Rainer A.C., Parr R.L., Woolcock P., Hoerr F., Collisson E.W.;
RT   "Comparisons of envelope through 5B sequences of infectious bronchitis
RT   coronaviruses indicates recombination occurs in the envelope and membrane
RT   genes.";
RL   Virus Res. 100:191-198(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Mondal S.P., Buckles E.L.;
RT   "Avian infectious bronchitis virus strain M41.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16934878; DOI=10.1016/j.jviromet.2006.07.018;
RA   Callison S.A., Hilt D.A., Boynton T.O., Sample B.F., Robison R.,
RA   Swayne D.E., Jackwood M.W.;
RT   "Development and evaluation of a real-time Taqman RT-PCR assay for the
RT   detection of infectious bronchitis virus from infected chickens.";
RL   J. Virol. Methods 138:60-65(2006).
RN   [4]
RP   FUNCTION.
RX   PubMed=27279618; DOI=10.1128/jvi.00627-16;
RA   Kint J., Langereis M.A., Maier H.J., Britton P., van Kuppeveld F.J.,
RA   Koumans J., Wiegertjes G.F., Forlenza M.;
RT   "Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing
RT   a Host Shutoff That Requires Accessory Protein 5b.";
RL   J. Virol. 90:7519-7528(2016).
CC   -!- FUNCTION: Involved in host translation shutoff without degradating host
CC       RNA. By suppressing host gene expression, facilitates the evasion from
CC       host type I interferon immune response. {ECO:0000269|PubMed:27279618}.
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DR   EMBL; AF469015; AAO33445.1; -; Genomic_RNA.
DR   EMBL; DQ834384; ABI26429.1; -; Genomic_RNA.
DR   EMBL; AY851295; AAW33792.1; -; Genomic_RNA.
DR   Proteomes; UP000007642; Genome.
DR   Proteomes; UP000096468; Genome.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR008458; Acc_prot_5b_avian_CoV.
DR   Pfam; PF05528; Coronavirus_5; 1.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Interferon antiviral system evasion.
FT   CHAIN           1..82
FT                   /note="Host translation inhibitor 5b"
FT                   /id="PRO_0000283927"
FT   VARIANT         45
FT                   /note="S -> P"
FT   VARIANT         75
FT                   /note="M -> T"
SQ   SEQUENCE   82 AA;  9329 MW;  17A9EBE969B8E12C CRC64;
     MNNSKDNPFC GAIARKARIY LREGLDCVYF LNKAGQAESC PACTSLVFQG KTCEEHKYNN
     NLLSWQAVRQ LERQMPQLQS SN