ID   NS6_BC279               Reviewed;          63 AA.
AC   Q0Q471;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=ORF6 protein;
DE            Short=ORF6;
DE   AltName: Full=Accessory protein 6;
DE   AltName: Full=Non-structural protein 6;
DE            Short=ns6;
GN   ORFNames=6;
OS   Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=389167;
OH   NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- FUNCTION: Could be a determinant of virus virulence. Seems to stimulate
CC       cellular DNA synthesis in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}. Host Golgi apparatus membrane {ECO:0000250}.
CC   -!- MISCELLANEOUS: Bat coronavirus 279/2005 is highly similar to SARS-CoV
CC       (SARS-like).
CC   -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family.
CC       {ECO:0000305}.
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DR   EMBL; DQ648857; ABG47073.1; -; Genomic_RNA.
DR   SMR; Q0Q471; -.
DR   Proteomes; UP000006573; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022736; NS6_bCoV.
DR   Pfam; PF12133; bCoV_NS6; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; Membrane;
KW   Virulence.
FT   CHAIN           1..63
FT                   /note="ORF6 protein"
FT                   /id="PRO_0000289892"
SQ   SEQUENCE   63 AA;  7513 MW;  9A13CD878EFBB4AD CRC64;
     MFHLVDFQVT IAEILIIIMK TFRVAIWNLD ILISSIVRQL FKPLTKKKYS ELDDEEPMEL
     DYP