ID   NS6_BCRP3               Reviewed;          63 AA.
AC   Q3I5J1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=ORF6 protein;
DE            Short=ORF6;
DE   AltName: Full=Accessory protein 6;
DE   AltName: Full=Non-structural protein 6;
DE            Short=ns6;
GN   ORFNames=6;
OS   Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=349344;
OH   NCBI_TaxID=59479; Rhinolophus ferrumequinum (Greater horseshoe bat).
OH   NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
OH   NCBI_TaxID=188571; Rhinolophus pearsonii.
OH   NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16195424; DOI=10.1126/science.1118391;
RA   Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H., Crameri G.,
RA   Hu Z., Zhang H., Zhang J., McEachern J., Field H., Daszak P., Eaton B.T.,
RA   Zhang S., Wang L.F.;
RT   "Bats are natural reservoirs of SARS-like coronaviruses.";
RL   Science 310:676-679(2005).
CC   -!- FUNCTION: Could be a determinant of virus virulence. Seems to stimulate
CC       cellular DNA synthesis in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}. Host Golgi apparatus membrane {ECO:0000250}.
CC   -!- MISCELLANEOUS: Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-
CC       like).
CC   -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family.
CC       {ECO:0000305}.
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DR   EMBL; DQ071615; AAZ67056.1; -; Genomic_RNA.
DR   SMR; Q3I5J1; -.
DR   Proteomes; UP000006570; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022736; NS6_bCoV.
DR   Pfam; PF12133; bCoV_NS6; 1.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; Membrane;
KW   Virulence.
FT   CHAIN           1..63
FT                   /note="ORF6 protein"
FT                   /id="PRO_0000106133"
SQ   SEQUENCE   63 AA;  7513 MW;  9A13CD878EFBB4AD CRC64;
     MFHLVDFQVT IAEILIIIMK TFRVAIWNLD ILISSIVRQL FKPLTKKKYS ELDDEEPMEL
     DYP