NS7A_BCRP3
ID NS7A_BCRP3 Reviewed; 122 AA.
AC Q3I5J0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 29-SEP-2021, entry version 67.
DE RecName: Full=Protein 7a;
DE AltName: Full=Accessory protein 7a;
DE Flags: Precursor;
GN ORFNames=7a;
OS Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Sarbecovirus.
OX NCBI_TaxID=349344;
OH NCBI_TaxID=59479; Rhinolophus ferrumequinum (Greater horseshoe bat).
OH NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
OH NCBI_TaxID=188571; Rhinolophus pearsonii.
OH NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16195424; DOI=10.1126/science.1118391;
RA Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H., Crameri G.,
RA Hu Z., Zhang H., Zhang J., McEachern J., Field H., Daszak P., Eaton B.T.,
RA Zhang S., Wang L.F.;
RT "Bats are natural reservoirs of SARS-like coronaviruses.";
RL Science 310:676-679(2005).
CC -!- FUNCTION: Non-structural protein which is dispensable for virus
CC replication in cell culture. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the spike glycoprotein, M protein, E protein
CC and the accessory protein 3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host endoplasmic reticulum
CC membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC Host endoplasmic reticulum-Golgi intermediate compartment membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host
CC Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein
CC {ECO:0000250}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250}.
CC -!- MISCELLANEOUS: Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-
CC like).
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DR EMBL; DQ071615; AAZ67057.1; -; Genomic_RNA.
DR BMRB; Q3I5J0; -.
DR SMR; Q3I5J0; -.
DR Proteomes; UP000006570; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1550; -; 1.
DR InterPro; IPR014888; ORF7a_SARS-CoV-like.
DR InterPro; IPR044871; ORF7a_SARS-CoV-like_X4e.
DR InterPro; IPR036495; ORF7a_sf_CoV.
DR Pfam; PF08779; bCoV_NS7A; 1.
DR SUPFAM; SSF117066; SSF117066; 1.
DR PROSITE; PS51919; X4E; 1.
PE 3: Inferred from homology;
KW Disulfide bond; G0/G1 host cell cycle checkpoint dysregulation by virus;
KW Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
KW Host-virus interaction; Membrane; Modulation of host cell cycle by virus;
KW Signal; Transmembrane; Transmembrane helix; Virion.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..122
FT /note="Protein 7a"
FT /id="PRO_0000043093"
FT TOPO_DOM 16..96
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..122
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT DOMAIN 16..81
FT /note="X4e"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267"
FT MOTIF 118..122
FT /note="Di-lysine motif"
FT /evidence="ECO:0000250"
FT DISULFID 23..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267"
FT DISULFID 35..67
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267"
SQ SEQUENCE 122 AA; 13846 MW; 4FDD97A37592D6D6 CRC64;
MKIILFLTLI ALASCELYHY QECVRGTTVL LKEPCPSGTY EGNSPFHPLA DNKFALTCTS
THFAFACADG TRHTYQLRAR SVSPKLFIRQ EEVHQELYSP LFLIVAALVF ITLCFTIKRK
TE
