ID   NS7B_SARS               Reviewed;          44 AA.
AC   Q7TFA1; Q7TLC9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Protein non-structural 7b;
DE            Short=ns7b;
DE   AltName: Full=Accessory protein 7b;
GN   ORFNames=7b;
OS   Severe acute respiratory syndrome coronavirus (SARS-CoV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=694009;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Urbani;
RX   PubMed=12730500; DOI=10.1126/science.1085952;
RA   Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
RA   Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S.,
RA   Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D.,
RA   Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S.,
RA   Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R.,
RA   Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J.,
RA   Bellini W.J.;
RT   "Characterization of a novel coronavirus associated with severe acute
RT   respiratory syndrome.";
RL   Science 300:1394-1399(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Tor2;
RX   PubMed=12730501; DOI=10.1126/science.1085953;
RA   Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
RA   Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
RA   Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R.,
RA   Mayo M., McDonald H., Montgomery S.B., Pandoh P.K., Petrescu A.S.,
RA   Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M.,
RA   Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K.,
RA   Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R.,
RA   Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A.,
RA   Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S.,
RA   Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M.,
RA   Skowronski D.M., Upton C., Roper R.L.;
RT   "The genome sequence of the SARS-associated coronavirus.";
RL   Science 300:1399-1404(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Frankfurt 1;
RX   PubMed=12917450; DOI=10.1099/vir.0.19424-0;
RA   Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S.,
RA   Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E.,
RA   Ziebuhr J.;
RT   "Mechanisms and enzymes involved in SARS coronavirus genome expression.";
RL   J. Gen. Virol. 84:2305-2315(2003).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=17037516; DOI=10.1007/978-0-387-33012-9_20;
RA   Pekosz A., Schaecher S.R., Diamond M.S., Fremont D.H., Sims A.C.,
RA   Baric R.S.;
RT   "Structure, expression, and intracellular localization of the SARS-CoV
RT   accessory proteins 7a and 7b.";
RL   Adv. Exp. Med. Biol. 581:115-120(2006).
CC   -!- INTERACTION:
CC       Q7TFA1; P59637: E; NbExp=2; IntAct=EBI-25492846, EBI-25487741;
CC       Q7TFA1; Q19QW5: ORF6; NbExp=2; IntAct=EBI-25492846, EBI-25493595;
CC       Q7TFA1; Q7Z434: MAVS; Xeno; NbExp=2; IntAct=EBI-25492846, EBI-995373;
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY278741; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY274119; AAP41044.1; -; Genomic_RNA.
DR   EMBL; AY291315; AAP33704.1; -; Genomic_RNA.
DR   RefSeq; NP_849175.1; NC_004718.3.
DR   SMR; Q7TFA1; -.
DR   BioGRID; 4383921; 260.
DR   IntAct; Q7TFA1; 255.
DR   GeneID; 1489675; -.
DR   SIGNOR; Q7TFA1; -.
DR   Proteomes; UP000000354; Genome.
DR   Proteomes; UP000137377; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd21635; ORF7b_SARS-CoV-like; 1.
DR   InterPro; IPR021532; NS7B_bCoV.
DR   InterPro; IPR044394; ORF7b_SARS-CoV-like.
DR   Pfam; PF11395; bCoV_NS7B; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..44
FT                   /note="Protein non-structural 7b"
FT                   /id="PRO_0000283857"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   44 AA;  5302 MW;  7AD647C9E311E04F CRC64;
     MNELTLIDFY LCFLAFLLFL VLIMLIIFWF SLEIQDLEEP CTKV