NS7_CVPPU
ID NS7_CVPPU Reviewed; 78 AA.
AC P04136; Q779N2;
DT 01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 02-JUN-2021, entry version 78.
DE RecName: Full=Non-structural protein 7;
DE Short=ns7;
DE AltName: Full=9 kDa hydrophobic protein;
DE Short=HP;
DE AltName: Full=Accessory protein 7;
DE AltName: Full=X3 protein;
DE Flags: Precursor;
GN ORFNames=7;
OS Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Tegacovirus.
OX NCBI_TaxID=11151;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2825819; DOI=10.1016/0300-9084(87)90178-7;
RA Rasschaert D., Gelfi J., Laude H.;
RT "Enteric coronavirus TGEV: partial sequence of the genomic RNA, its
RT organization and expression.";
RL Biochimie 69:591-600(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3008432; DOI=10.1016/0042-6822(86)90102-9;
RA Kapke P.A., Brian D.A.;
RT "Sequence analysis of the porcine transmissible gastroenteritis coronavirus
RT nucleocapsid protein gene.";
RL Virology 151:41-49(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate PUR46-MAD;
RX PubMed=10805807; DOI=10.1073/pnas.97.10.5516;
RA Almazan F., Gonzalez J.M., Penzes Z., Izeta A., Calvo E., Plana-Duran J.,
RA Enjuanes L.;
RT "Engineering the largest RNA virus genome as an infectious bacterial
RT artificial chromosome.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:5516-5521(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=15240950; DOI=10.1292/jvms.66.717;
RA Taniguchi T., Taniguchi R., Takahashi A., Hayashidani H., Hanaki K.,
RA Shirai J., Honda E.;
RT "Sequence comparison of the ORF 7 region of transmissible gastroenteritis
RT viruses isolated in Japan.";
RL J. Vet. Med. Sci. 66:717-719(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Isolate SC-1, and SC-Y;
RA Ou Y., Yan Q.G., Guo W.Z.;
RT "Cloning and sequence analysis of Orf7 gene from transmissible
RT gastroenteritis virus of porcine strain SC-Y.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=SC-Y;
RA Song Z.H., Guo W.Z., Yin H.P., Zeng Z.Y., Ou Y., Han G.Q., Sun Z.Y.;
RT "Cloning and Seqence Analysis of Genome of Transmissible gastroenteritis
RT virus SC-Y strain.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=1310191; DOI=10.1016/0042-6822(92)90034-m;
RA Tung F.Y.T., Abraham S., Sethna M., Hung S.-L., Sethna P.B., Hogue B.A.,
RA Brian D.A.;
RT "The 9-kDa hydrophobic protein encoded at the 3' end of the porcine
RT transmissible gastroenteritis coronavirus genome is membrane-associated.";
RL Virology 186:676-683(1992).
CC -!- FUNCTION: May function in the formation of membrane-bound replication
CC complexes or in the assembly of the virus.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the coronaviruses ns7/ns7a protein family.
CC {ECO:0000305}.
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DR EMBL; X06371; CAA29675.1; -; Genomic_RNA.
DR EMBL; M14878; AAA47916.1; -; Genomic_RNA.
DR EMBL; AJ271965; CAB91151.1; -; Genomic_RNA.
DR EMBL; AB115410; BAD34531.1; -; Genomic_RNA.
DR EMBL; DQ437506; ABD78841.1; -; mRNA.
DR EMBL; DQ437507; ABD78842.1; -; mRNA.
DR EMBL; DQ443743; ABD97841.1; -; Genomic_RNA.
DR PIR; S03937; QQIHPC.
DR Proteomes; UP000001440; Genome.
DR Proteomes; UP000158504; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR003449; Corona_7.
DR Pfam; PF02398; Corona_7; 2.
PE 3: Inferred from homology;
KW Host membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..78
FT /note="Non-structural protein 7"
FT /id="PRO_0000106099"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 30
FT /note="N -> D (in Ref. 2; AAA47916)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="M -> V (in Ref. 2; AAA47916)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 78 AA; 9130 MW; 7E4F11F864A6B644 CRC64;
MLVFLHAVFI TVLILLLIGR LQLLERLLLN HSFNLKTVND FNILYRSLAE TRLLKVVLRV
IFLVLLGFCC YRLLVTLM