ID   NS8A_SARS               Reviewed;          39 AA.
AC   Q7TFA0; Q7TLC8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=ORF8a protein;
DE   AltName: Full=Accessory protein 8a;
DE   AltName: Full=Protein non-structural 8a;
DE            Short=ns8a;
DE   Flags: Precursor;
GN   ORFNames=8a;
OS   Severe acute respiratory syndrome coronavirus (SARS-CoV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=694009;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Urbani;
RX   PubMed=12730500; DOI=10.1126/science.1085952;
RA   Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
RA   Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S.,
RA   Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D.,
RA   Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S.,
RA   Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R.,
RA   Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J.,
RA   Bellini W.J.;
RT   "Characterization of a novel coronavirus associated with severe acute
RT   respiratory syndrome.";
RL   Science 300:1394-1399(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Tor2;
RX   PubMed=12730501; DOI=10.1126/science.1085953;
RA   Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
RA   Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
RA   Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R.,
RA   Mayo M., McDonald H., Montgomery S.B., Pandoh P.K., Petrescu A.S.,
RA   Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M.,
RA   Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K.,
RA   Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R.,
RA   Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A.,
RA   Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S.,
RA   Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M.,
RA   Skowronski D.M., Upton C., Roper R.L.;
RT   "The genome sequence of the SARS-associated coronavirus.";
RL   Science 300:1399-1404(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Frankfurt 1;
RX   PubMed=12917450; DOI=10.1099/vir.0.19424-0;
RA   Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S.,
RA   Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E.,
RA   Ziebuhr J.;
RT   "Mechanisms and enzymes involved in SARS coronavirus genome expression.";
RL   J. Gen. Virol. 84:2305-2315(2003).
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DR   EMBL; AY278741; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY274119; AAP41045.1; -; Genomic_RNA.
DR   EMBL; AY291315; AAP33705.1; -; Genomic_RNA.
DR   RefSeq; NP_849176.1; NC_004718.3.
DR   BioGRID; 4383922; 29.
DR   IntAct; Q7TFA0; 24.
DR   PRIDE; Q7TFA0; -.
DR   GeneID; 1489676; -.
DR   SIGNOR; Q7TFA0; -.
DR   Proteomes; UP000000354; Genome.
DR   Proteomes; UP000137377; Genome.
DR   InterPro; IPR022722; ORF8_betacoronavirus.
DR   Pfam; PF12093; bCoV_NS8; 1.
DR   PROSITE; PS51964; SARS_ORF8_IG; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..39
FT                   /note="ORF8a protein"
FT                   /id="PRO_0000283858"
FT   DOMAIN          16..39
FT                   /note="SARS ORF8 Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
SQ   SEQUENCE   39 AA;  4327 MW;  1F890982A820681F CRC64;
     MKLLIVLTCI SLCSCICTVV QRCASNKPHV LEDPCKVQH