ID   NS8_BC279               Reviewed;         121 AA.
AC   Q0Q469;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Non-structural protein 8;
DE            Short=ns8;
DE   AltName: Full=Accessory protein 8;
DE   Flags: Precursor;
GN   ORFNames=8;
OS   Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=389167;
OH   NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- MISCELLANEOUS: This protein corresponds nearly to the fused 8a and 8b
CC       proteins of SARS-CoV.
CC   -!- MISCELLANEOUS: Bat coronavirus 279/2005 is highly similar to SARS-CoV
CC       (SARS-like).
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DR   EMBL; DQ648857; ABG47075.1; -; Genomic_RNA.
DR   SMR; Q0Q469; -.
DR   TCDB; 1.C.99.1.3; the pore-forming corona viral orf8a (sars8a) family.
DR   Proteomes; UP000006573; Genome.
DR   CDD; cd21643; ORF8-Ig_bat_SARS-CoV_HKU3-1_type-III-like; 1.
DR   InterPro; IPR044393; ORF8_bat_SARS-CoV_HKU3-1-like.
DR   InterPro; IPR022722; ORF8_betacoronavirus.
DR   Pfam; PF12093; bCoV_NS8; 1.
DR   PROSITE; PS51964; SARS_ORF8_IG; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..121
FT                   /note="Non-structural protein 8"
FT                   /id="PRO_0000289895"
FT   DOMAIN          19..121
FT                   /note="SARS ORF8 Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        20
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        25..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        37..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        61..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
SQ   SEQUENCE   121 AA;  14102 MW;  C442FDC077C3F4DF CRC64;
     MKLLIVFGLL TSVYCIHKEC SIQECCENQP YQIEDPCPIH YYSDWFIKIG SRKSARLVQL
     CEGDYGKRIP IHYEMFGNYT ISCEPLEINC QAPPVGSLIV RCSYDYDFVE HHDVRVVLDF
     I