ID   NS8_BCHK3               Reviewed;         121 AA.
AC   Q3LZX5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   23-FEB-2022, entry version 41.
DE   RecName: Full=Non-structural protein 8;
DE            Short=ns8;
DE   AltName: Full=Accessory protein 8;
DE   Flags: Precursor;
GN   ORFNames=8;
OS   Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=442736;
OH   NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate HKU3-1;
RX   PubMed=16169905; DOI=10.1073/pnas.0506735102;
RA   Lau S.K.P., Woo P.C.Y., Li K.S.M., Huang Y., Tsoi H.-W., Wong B.H.L.,
RA   Wong S.S.Y., Leung S.-Y., Chan K.-H., Yuen K.-Y.;
RT   "Severe acute respiratory syndrome coronavirus-like virus in Chinese
RT   horseshoe bats.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:14040-14045(2005).
CC   -!- MISCELLANEOUS: This protein corresponds nearly to the fused 8a and 8b
CC       proteins of SARS-CoV.
CC   -!- MISCELLANEOUS: Bat coronavirus HKU3 is highly similar to SARS-CoV
CC       (SARS-like).
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DR   EMBL; DQ022305; AAY88873.1; -; Genomic_RNA.
DR   SMR; Q3LZX5; -.
DR   Proteomes; UP000007450; Genome.
DR   CDD; cd21643; ORF8-Ig_bat_SARS-CoV_HKU3-1_type-III-like; 1.
DR   InterPro; IPR044393; ORF8_bat_SARS-CoV_HKU3-1-like.
DR   InterPro; IPR022722; ORF8_betacoronavirus.
DR   Pfam; PF12093; bCoV_NS8; 1.
DR   PROSITE; PS51964; SARS_ORF8_IG; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..121
FT                   /note="Non-structural protein 8"
FT                   /id="PRO_0000291334"
FT   DOMAIN          19..121
FT                   /note="SARS ORF8 Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        20
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        25..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        37..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        61..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
SQ   SEQUENCE   121 AA;  14162 MW;  F3741B33A24B6475 CRC64;
     MKLLIVFGLL ASVYCFHREC SIQECCENQP YQIEDPCPIH YYSDWFIKIG SRKSARLVQL
     CEGDYGRRIP IHYEMFGNYT ISCEPLEINC QAPPVGSLIV RCSYDYDFVE HHDVRVVLDF
     I