ID   NS8_BCRP3               Reviewed;         121 AA.
AC   Q3I5I8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   23-FEB-2022, entry version 38.
DE   RecName: Full=Non-structural protein 8;
DE            Short=ns8;
DE   AltName: Full=Accessory protein 8;
DE   Flags: Precursor;
GN   ORFNames=8;
OS   Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=349344;
OH   NCBI_TaxID=59479; Rhinolophus ferrumequinum (Greater horseshoe bat).
OH   NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
OH   NCBI_TaxID=188571; Rhinolophus pearsonii.
OH   NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16195424; DOI=10.1126/science.1118391;
RA   Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H., Crameri G.,
RA   Hu Z., Zhang H., Zhang J., McEachern J., Field H., Daszak P., Eaton B.T.,
RA   Zhang S., Wang L.F.;
RT   "Bats are natural reservoirs of SARS-like coronaviruses.";
RL   Science 310:676-679(2005).
CC   -!- MISCELLANEOUS: This protein corresponds nearly to the fused 8a and 8b
CC       proteins of SARS-CoV.
CC   -!- MISCELLANEOUS: Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-
CC       like).
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DR   EMBL; DQ071615; AAZ67059.1; -; Genomic_RNA.
DR   SMR; Q3I5I8; -.
DR   Proteomes; UP000006570; Genome.
DR   CDD; cd21643; ORF8-Ig_bat_SARS-CoV_HKU3-1_type-III-like; 1.
DR   InterPro; IPR044393; ORF8_bat_SARS-CoV_HKU3-1-like.
DR   InterPro; IPR022722; ORF8_betacoronavirus.
DR   Pfam; PF12093; bCoV_NS8; 1.
DR   PROSITE; PS51964; SARS_ORF8_IG; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..121
FT                   /note="Non-structural protein 8"
FT                   /id="PRO_0000043094"
FT   DOMAIN          19..121
FT                   /note="SARS ORF8 Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        20
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        25..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        37..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
FT   DISULFID        61..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01309"
SQ   SEQUENCE   121 AA;  14087 MW;  A0098B0077C3F4CF CRC64;
     MKLLIVFGLL TSVYCIHKEC SIQECCENQP YQIEDPCPIH YYSDWFIKIG SRKSARLVQL
     CEGDYGKRIP IHYQMFGNYT ISCEPLEINC QAPPVGSLIV RCSYDYDFVE HHDVRVVLDF
     V