ID   NSA1_ASHGO              Reviewed;         435 AA.
AC   Q754U4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Ribosome biogenesis protein NSA1;
GN   Name=NSA1; OrderedLocusNames=AFL023C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NSA1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53349.1; -; Genomic_DNA.
DR   RefSeq; NP_985525.1; NM_210879.1.
DR   AlphaFoldDB; Q754U4; -.
DR   SMR; Q754U4; -.
DR   STRING; 33169.AAS53349; -.
DR   EnsemblFungi; AAS53349; AAS53349; AGOS_AFL023C.
DR   GeneID; 4621758; -.
DR   KEGG; ago:AGOS_AFL023C; -.
DR   eggNOG; KOG3881; Eukaryota.
DR   HOGENOM; CLU_033769_4_0_1; -.
DR   InParanoid; Q754U4; -.
DR   OMA; IWEAKNV; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037379; WDR74/Nsa1.
DR   PANTHER; PTHR16038; PTHR16038; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..435
FT                   /note="Ribosome biogenesis protein NSA1"
FT                   /id="PRO_0000320395"
FT   REGION          394..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..435
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  48943 MW;  BB9B244D1FBF1069 CRC64;
     MRLLIGSDDS GCIKELVANR GTNTSEQSAL QPLHLEAHLE RGLNAKAHQM LQISDNECLL
     ARMSGDIELV SWSREPRGGE EDKPVFEVSS FQVMATLGGL LDGEKMQELH KRSQRRAASA
     DRFVALFALP GQPQRYFAAT MSGQFHFLAL ADGDLKLQKT FSVRGPVEFA QLYDLEETEK
     LVFAYGGEDN LIKLVEVSRD LEQLEQIWEA KNVKNDRLDL KVPIWPAALR FLQPAVSPAS
     EGLNYQFIAV TRHSHLHFYQ TTHGRKPFRS VDLLPNREPT TSLEVVGDVT PLGNVKSTSF
     EGFSIITTDT KKSILQFEPS GHLLGKFGGS DIKGFPSYIH VQGKYLVEGG LDRYVRVFEL
     KNRNMLLKVF AGGKVSSVLL LDVSDVELPL SKKEKNKRRH KRVLDEDQER EEDNELWAQL
     DGSSKRRKSK PRLDG