ID   NSA1_CANAL              Reviewed;         406 AA.
AC   Q5A2T0; A0A1D8PI72;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Ribosome biogenesis protein NSA1;
GN   Name=NSA1; OrderedLocusNames=CAALFM_C207960CA;
GN   ORFNames=CaO19.2185, CaO19.9731;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NSA1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27792.1; -; Genomic_DNA.
DR   RefSeq; XP_716026.1; XM_710933.2.
DR   AlphaFoldDB; Q5A2T0; -.
DR   SMR; Q5A2T0; -.
DR   STRING; 237561.Q5A2T0; -.
DR   GeneID; 3642313; -.
DR   KEGG; cal:CAALFM_C207960CA; -.
DR   CGD; CAL0000184567; NSA1.
DR   VEuPathDB; FungiDB:C2_07960C_A; -.
DR   eggNOG; KOG3881; Eukaryota.
DR   HOGENOM; CLU_033769_4_0_1; -.
DR   InParanoid; Q5A2T0; -.
DR   OMA; IWEAKNV; -.
DR   OrthoDB; 1439033at2759; -.
DR   PRO; PR:Q5A2T0; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037379; WDR74/Nsa1.
DR   PANTHER; PTHR16038; PTHR16038; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..406
FT                   /note="Ribosome biogenesis protein NSA1"
FT                   /id="PRO_0000320396"
FT   REGION          373..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..406
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45966 MW;  B367E013A1DCA3FC CRC64;
     MKVIVSADDT GSAKEVICNE GTDTSKQNAT QPISIDNCLL EPSSSVKSRI IHFLSFNYQY
     LIGARLGGQV SVYELSDEES EEKFKLLHNF ELPVDAQDKP VALLRVEILD SILVAFESSK
     VFLIHINDSF DFKPLELVLP EYKPISAFAI NPQAENIVAL GGKEHDLQIL QLFNKNINST
     VFKKNNYENE FKPQIIFKAK NVRNDHLELR VPIWITNILF AKAAKGYKLV TSTRYGQIRL
     YDTAEGRKPR KDYKVTEKPI VTLTFANDEQ TEIIVTDTHS LIAKYSLTQV DEKAFKTISA
     SAGEIVKPVP KLLGKFTGGN TGATFGVHAY ERIVAFAGLD RYLRVFDLES REILAKVYLG
     VEVSALLILD DEDTEDEETK KRKRKEEEDD EELWNQLDTK KKTHTI