ID   NSA1_KLULA              Reviewed;         436 AA.
AC   Q6CKH7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Ribosome biogenesis protein NSA1;
GN   Name=NSA1; OrderedLocusNames=KLLA0F10593g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NSA1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98270.1; -; Genomic_DNA.
DR   RefSeq; XP_455562.1; XM_455562.1.
DR   AlphaFoldDB; Q6CKH7; -.
DR   SMR; Q6CKH7; -.
DR   STRING; 28985.XP_455562.1; -.
DR   EnsemblFungi; CAG98270; CAG98270; KLLA0_F10593g.
DR   GeneID; 2895729; -.
DR   KEGG; kla:KLLA0_F10593g; -.
DR   eggNOG; KOG3881; Eukaryota.
DR   HOGENOM; CLU_033769_4_0_1; -.
DR   InParanoid; Q6CKH7; -.
DR   OMA; IWEAKNV; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037379; WDR74/Nsa1.
DR   PANTHER; PTHR16038; PTHR16038; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..436
FT                   /note="Ribosome biogenesis protein NSA1"
FT                   /id="PRO_0000320399"
SQ   SEQUENCE   436 AA;  49161 MW;  A7D1BB88484289B0 CRC64;
     MRVLLASDDS GSLKEIIFNR GTNTSIKTAL QPFHIDIHLN QGLSNRIDKI YHVSDSLLLL
     ARHSGSLELV SSKRVSKDVD ETNEPKYDVT EFELQDLISG LFDQSVLDTL SSKSKKKSKI
     EDQFVELYLI KKSAKNPIFL AATKSGNVTI IEVDLHSTKI SKIASHKIKA PVEFVTLYDL
     DKSDKFVMAY GGEENLVRLI ELSSDFKEIS DIWAAKNVPF DNIGLRVPAW DVALRFLESE
     KNGVYNFITI TKYAQLRKYS TNAEDCRPVK SITLLPKGEQ LNSCKIIGDT SPLGNFQSSN
     FDELEFLAAD SRKDVYQFNG KGRLLRKIAK GDITGFASCI AVTDKYLLQG GLDRYVRIFD
     LADYKLLAKI FTGGKVSDII LLEDNDLELP LTEKQLKMKK KKEAKRSIVE ADEDAENEDL
     WNKLESKKRK VSKNDI