ID   NSA1_LODEL              Reviewed;         447 AA.
AC   A5DX41;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ribosome biogenesis protein NSA1;
GN   Name=NSA1; ORFNames=LELG_01928;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NSA1 family. {ECO:0000305}.
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DR   EMBL; CH981525; EDK43749.1; -; Genomic_DNA.
DR   RefSeq; XP_001527099.1; XM_001527049.1.
DR   AlphaFoldDB; A5DX41; -.
DR   SMR; A5DX41; -.
DR   STRING; 379508.A5DX41; -.
DR   EnsemblFungi; EDK43749; EDK43749; LELG_01928.
DR   GeneID; 5233760; -.
DR   KEGG; lel:LELG_01928; -.
DR   VEuPathDB; FungiDB:LELG_01928; -.
DR   eggNOG; KOG3881; Eukaryota.
DR   HOGENOM; CLU_033769_4_0_1; -.
DR   InParanoid; A5DX41; -.
DR   OMA; IWEAKNV; -.
DR   OrthoDB; 1439033at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR037379; WDR74/Nsa1.
DR   PANTHER; PTHR16038; PTHR16038; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..447
FT                   /note="Ribosome biogenesis protein NSA1"
FT                   /id="PRO_0000320400"
FT   REGION          83..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  50728 MW;  842AD71831D3D76A CRC64;
     MKVLTTCDDT GAAKLCSFKR GTDTSKKDAT QPDLIENCMN LPKSNYKTRI IHLINYNYQY
     FIASRLGGTL SIYDYEENDV AMKPQEKQEG NGSKSDKEQK SSLKVESEST NSKENIEEVA
     GYVEERFKFL HEFKLPVSMN DRPIALQKCE KLDSVLVAYE SGKVYLVYVG DFSFEPLLLH
     LPGCTHLNAF AIHPEQENVV AFGGKETDLQ IAELYNSSVN SKIFKKDYKS AFVPKILFKA
     KNVSNDHLNL RVPIWITNIL FFTNNVTNGQ YKLITSTRYG QLRIYDTKHG RKPVKDYPVS
     TTPILTLLFG NDKETEVVLT DTQNLMAKYS LDIIDDKAFK TNSASAGDII KPVPKLLGKY
     TGGNTGATLA QQVYEGIVAF AGLDRYLRVF DVESRQILAK VYLGVEVSSL IIIDDEDEEN
     EEEQKRKRDE EEEDNEMWSQ LDKKQKV