NSA1_PICGU
ID NSA1_PICGU Reviewed; 398 AA.
AC A5DKC4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Ribosome biogenesis protein NSA1;
GN Name=NSA1; ORFNames=PGUG_03725;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NSA1 family. {ECO:0000305}.
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DR EMBL; CH408158; EDK39627.2; -; Genomic_DNA.
DR RefSeq; XP_001484344.1; XM_001484294.1.
DR AlphaFoldDB; A5DKC4; -.
DR SMR; A5DKC4; -.
DR STRING; 4929.XP_001484344.1; -.
DR EnsemblFungi; EDK39627; EDK39627; PGUG_03725.
DR GeneID; 5126180; -.
DR KEGG; pgu:PGUG_03725; -.
DR eggNOG; KOG3881; Eukaryota.
DR HOGENOM; CLU_033769_4_0_1; -.
DR InParanoid; A5DKC4; -.
DR OMA; YTGTTMG; -.
DR OrthoDB; 1439033at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR037379; WDR74/Nsa1.
DR PANTHER; PTHR16038; PTHR16038; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..398
FT /note="Ribosome biogenesis protein NSA1"
FT /id="PRO_0000320401"
FT REGION 364..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..382
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44613 MW; 58794A4CC3E98BFE CRC64;
MRLIVTCDDS GSAQGGDFVL QEQIPRNRTS PSPISITQVF VEPKASPASR ILYSTLYKER
YAICCRLDAS VSVYDLEDDE KKLVCHREYV ELKGCKPVSL HVFSEFDALV MGLDSGKAAL
VGFHKNTLEK ECQIVDLPGG KPIEAFEACP SQPGVFAYGG KENDLRIVKM FEVGKKVKLL
ESVEVLFAAK NVKNDHLDLR VPIWITKIRF ISSKNSYKLI TATRYGQLRI YDTNHGRKPA
HDYQVCTNPI ITLNFAGSNS DEVIITDNRN MVARHSLVSI DKKAFKTNSA TVGDIIKPVP
RLLGKYQEGG NTGAIFGVSC FKDTFVATGG LDRYLRVYDL ETREMVSKVY MGSQIADILF
LEGEEEEESE EEVDEEEENN ALWDELESNR PAKKQKQT
