NSA2_AJECN
ID NSA2_AJECN Reviewed; 261 AA.
AC A6R3Q6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Ribosome biogenesis protein NSA2;
GN Name=NSA2; ORFNames=HCAG_04264;
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC unclassified Histoplasma.
OX NCBI_TaxID=2059318;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC play a part in the quality control of pre-60S particles (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC {ECO:0000250|UniProtKB:P40078}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR EMBL; CH476658; EDN07754.1; -; Genomic_DNA.
DR RefSeq; XP_001540424.1; XM_001540374.1.
DR AlphaFoldDB; A6R3Q6; -.
DR SMR; A6R3Q6; -.
DR STRING; 339724.A6R3Q6; -.
DR EnsemblFungi; EDN07754; EDN07754; HCAG_04264.
DR GeneID; 5446825; -.
DR KEGG; aje:HCAG_04264; -.
DR VEuPathDB; FungiDB:HCAG_04264; -.
DR HOGENOM; CLU_1070048_0_0_1; -.
DR OMA; TKSWKRM; -.
DR OrthoDB; 1079827at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR CDD; cd11381; NSA2; 1.
DR InterPro; IPR039411; NSA2_fam.
DR InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR PANTHER; PTHR12642; PTHR12642; 1.
DR Pfam; PF01201; Ribosomal_S8e; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..261
FT /note="Ribosome biogenesis protein NSA2"
FT /id="PRO_0000320407"
FT REGION 28..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 51..58
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 53..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29845 MW; 8BC0A4D14159874F CRC64;
MPQNEYIERW QKQYGERLDH EERTRKRIAR EAHKQSHDAQ SFRGLRAKLY QKKRHAEKIE
MKKRIRAQEE KNVKSSAPNE PSSTPLPNYL LDRSQETNAK SLSSAIKNKR AEKAAQFSVP
LPKVKGISEE EMFKVVKTGK KTAKKSWKRM ITKPTFVGAD FTRRPVKYER FIRPMGLRYK
KANVTHPKLG VTVQLPIISV KKNPQSPMYT QLGVLTKGTI IEVNVSELGQ VTASGKVLWG
KFAQITNNCE NDGCVNAVLL V