ID   NSA2_BOVIN              Reviewed;         260 AA.
AC   Q3SX11;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Ribosome biogenesis protein NSA2 homolog;
DE   AltName: Full=TGF-beta-inducible nuclear protein 1;
GN   Name=NSA2; Synonyms=TINP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; BC104563; AAI04564.1; -; mRNA.
DR   RefSeq; NP_001029718.1; NM_001034546.2.
DR   AlphaFoldDB; Q3SX11; -.
DR   SMR; Q3SX11; -.
DR   STRING; 9913.ENSBTAP00000003989; -.
DR   PaxDb; Q3SX11; -.
DR   PRIDE; Q3SX11; -.
DR   Ensembl; ENSBTAT00000003989; ENSBTAP00000003989; ENSBTAG00000003066.
DR   GeneID; 522309; -.
DR   KEGG; bta:522309; -.
DR   CTD; 10412; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003066; -.
DR   eggNOG; KOG3163; Eukaryota.
DR   GeneTree; ENSGT00390000018706; -.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q3SX11; -.
DR   OMA; TKSWKRM; -.
DR   OrthoDB; 1079827at2759; -.
DR   TreeFam; TF300766; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000003066; Expressed in myometrium and 103 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosome biogenesis; rRNA processing; Ubl conjugation.
FT   CHAIN           1..260
FT                   /note="Ribosome biogenesis protein NSA2 homolog"
FT                   /id="PRO_0000231007"
FT   REGION          20..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           11..18
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        20..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         81
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O95478"
FT   CROSSLNK        80
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O95478"
SQ   SEQUENCE   260 AA;  30035 MW;  D89FF5A9655F8E41 CRC64;
     MPQNEYIELH RKRYGYRLDY HEKKRKKEGR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ
     MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP
     LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMGLRFKK
     AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK
     YAQVTNNPEN DGCINAVLLV