ID   NSA2_CANAL              Reviewed;         261 AA.
AC   Q5A2Y7; A0A1D8PKJ6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Ribosome biogenesis protein NSA2;
GN   Name=NSA2; OrderedLocusNames=CAALFM_C306380WA; ORFNames=CaO19.7424;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; CP017625; AOW28645.1; -; Genomic_DNA.
DR   RefSeq; XP_716088.1; XM_710995.1.
DR   RefSeq; XP_716639.2; XM_711546.2.
DR   AlphaFoldDB; Q5A2Y7; -.
DR   SMR; Q5A2Y7; -.
DR   BioGRID; 1225353; 2.
DR   STRING; 237561.Q5A2Y7; -.
DR   GeneID; 3641766; -.
DR   GeneID; 3642259; -.
DR   KEGG; cal:CAALFM_C306160CA; -.
DR   KEGG; cal:CAALFM_C306380WA; -.
DR   CGD; CAL0000197650; NSA2.
DR   CGD; CAL0000192673; orf19.7397.1.
DR   VEuPathDB; FungiDB:C3_06160C_A; -.
DR   VEuPathDB; FungiDB:C3_06380W_A; -.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q5A2Y7; -.
DR   OMA; TKSWKRM; -.
DR   OrthoDB; 1079827at2759; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..261
FT                   /note="Ribosome biogenesis protein NSA2"
FT                   /id="PRO_0000320412"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           11..18
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           51..58
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        7..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29578 MW;  3386DFB1E4F2BD82 CRC64;
     MPQNEYIEQH IKKHGRRLDY EERKRKKEAR EGHRVAKDAQ TLKGWRAKQF AKKRYAEKVA
     MKKKIKAHQE SKVKGPSTPK AEDGEALPTY LLDRQTNNTA KAISSSIKQK RLEKADKFQV
     PLPKVKGISE EEMFKVIKTG KSKSKSWKRM ITKHTFVGEG FTRRPVKMER IIRPAALRQK
     KANVTHPELG VTVFLPILGV KKNPQSPMYT QLGVLTKGTI IEVNVSELGL VTAGGKVVWG
     KYAQITNEPD RDGCVNAVLL V