ID   NSA2_COCIM              Reviewed;         261 AA.
AC   Q1DQ27; A0A0D6K9M8; J3K4C2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ribosome biogenesis protein NSA2;
GN   Name=NSA2; ORFNames=CIMG_07586;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; GG704913; EAS28840.2; -; Genomic_DNA.
DR   RefSeq; XP_001240423.2; XM_001240422.2.
DR   AlphaFoldDB; Q1DQ27; -.
DR   SMR; Q1DQ27; -.
DR   STRING; 246410.Q1DQ27; -.
DR   EnsemblFungi; EAS28840; EAS28840; CIMG_07586.
DR   GeneID; 4560082; -.
DR   KEGG; cim:CIMG_07586; -.
DR   VEuPathDB; FungiDB:CIMG_07586; -.
DR   InParanoid; Q1DQ27; -.
DR   OMA; TKSWKRM; -.
DR   OrthoDB; 1079827at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..261
FT                   /note="Ribosome biogenesis protein NSA2"
FT                   /id="PRO_0000320414"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           15..22
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           51..58
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        9..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..61
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29835 MW;  8B740290821C17F9 CRC64;
     MPQNEYIERW QKQHGKRLDH EERTRKRIAR ESHKQSQDAQ TLRGLRAKLY HKKRHAEKIQ
     MRKRIKAQEE RDVKSAAPNE PSTTPLPQYL LDRSQATNAK ALSSAIKEKR AEKAAKFSVP
     LPKVKGISEE EMFKVVKTGK KTSKKSWKRM ITKPTFVGND FTRRPVKYER FIRPMGLRYK
     KANVTHPELG VTVQLPIISV KKNPQSPMYT QLGVLTKGTI IEVNVSELGL VTAGGKVVWG
     KWAQITNNCE NDGCVNAVLL V