ID   NSA2_DEBHA              Reviewed;         261 AA.
AC   Q6BU14;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Ribosome biogenesis protein NSA2;
GN   Name=NSA2; OrderedLocusNames=DEHA2C14322g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; CR382135; CAG86383.1; -; Genomic_DNA.
DR   RefSeq; XP_458305.1; XM_458305.1.
DR   AlphaFoldDB; Q6BU14; -.
DR   SMR; Q6BU14; -.
DR   STRING; 4959.XP_458305.1; -.
DR   EnsemblFungi; CAG86383; CAG86383; DEHA2C14322g.
DR   GeneID; 2900320; -.
DR   KEGG; dha:DEHA2C14322g; -.
DR   VEuPathDB; FungiDB:DEHA2C14322g; -.
DR   eggNOG; KOG3163; Eukaryota.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q6BU14; -.
DR   OMA; TKSWKRM; -.
DR   OrthoDB; 1079827at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..261
FT                   /note="Ribosome biogenesis protein NSA2"
FT                   /id="PRO_0000320416"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           15..22
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           51..58
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        9..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29634 MW;  00B61E05A7988A2F CRC64;
     MPQNEYIEQH IKQHGRRLDY EERKRKKAAR EGHRIAKDAQ ELKGWRGKQF AKKRYSEKVA
     MKKKIKTHQE SKVKGPATPK EDDGEALPTY LLDRQTNNSA KAISSSIKQK RLEKADKFAV
     PLPRVKGISE EEMFKVIKTG KQKSKAWKRM ITKHTFVGEG FTRRPVKMER IIRPSALRQK
     KANVTHPELA VTVFLPILGV KKNPQSPMYT QLGVLTKGTI IEVNVSELGL VTAGGKVVWG
     KYAQITNEPD RDGCVNAVLL V