ID   NSA2_DICDI              Reviewed;         260 AA.
AC   Q54GN8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Ribosome biogenesis protein NSA2 homolog;
GN   Name=nsa2; ORFNames=DDB_G0290031;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000151; EAL62421.1; -; Genomic_DNA.
DR   RefSeq; XP_635924.1; XM_630832.1.
DR   AlphaFoldDB; Q54GN8; -.
DR   SMR; Q54GN8; -.
DR   STRING; 44689.DDB0188692; -.
DR   PaxDb; Q54GN8; -.
DR   EnsemblProtists; EAL62421; EAL62421; DDB_G0290031.
DR   GeneID; 8627445; -.
DR   KEGG; ddi:DDB_G0290031; -.
DR   dictyBase; DDB_G0290031; -.
DR   eggNOG; KOG3163; Eukaryota.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q54GN8; -.
DR   OMA; TKSWKRM; -.
DR   PhylomeDB; Q54GN8; -.
DR   PRO; PR:Q54GN8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..260
FT                   /note="Ribosome biogenesis protein NSA2 homolog"
FT                   /id="PRO_0000320429"
FT   MOTIF           11..18
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ   SEQUENCE   260 AA;  29680 MW;  7F0E1E9C678A7CB7 CRC64;
     MPQGDHIELH QKRFGRRLDH YEKVRKKTAR AAHKRSAIAQ KVTGLKAKLY NKKRYSEKAE
     MKKTIAMHQE RTNKKASDDK VKEGAVPAYL LDREGVSRAK VLSNMVKQKR KEKAGKWDVP
     LPKVRAISED EMFKVVKSGK RQKKAWKRFV TKVTFVGEGF TRKPPKYERF IRPTGLRFKK
     AHVTHPELKS TFYLDILSVK KNPQSPTYTQ LGVITKGTIL EVNVSDLGLV TQTGKVVWGK
     MAQVTNNPEN DGCINAVLLV