NSA2_EMENI
ID NSA2_EMENI Reviewed; 261 AA.
AC Q5B954; C8VJ56;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Ribosome biogenesis protein nsa2;
GN Name=nsa2; ORFNames=AN2926;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC play a part in the quality control of pre-60S particles (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC nop7 and rrp1. Interacts with rsa4 (via WD repeats).
CC {ECO:0000250|UniProtKB:P40078}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF83736.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA63497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000051; EAA63497.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001306; CBF83736.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_660530.1; XM_655438.1.
DR AlphaFoldDB; Q5B954; -.
DR SMR; Q5B954; -.
DR STRING; 162425.CADANIAP00010162; -.
DR PRIDE; Q5B954; -.
DR EnsemblFungi; EAA63497; EAA63497; AN2926.2.
DR GeneID; 2874412; -.
DR KEGG; ani:AN2926.2; -.
DR VEuPathDB; FungiDB:AN2926; -.
DR eggNOG; KOG3163; Eukaryota.
DR HOGENOM; CLU_1070048_0_0_1; -.
DR InParanoid; Q5B954; -.
DR OrthoDB; 1079827at2759; -.
DR Proteomes; UP000000560; Chromosome VI.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR CDD; cd11381; NSA2; 1.
DR InterPro; IPR039411; NSA2_fam.
DR InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR PANTHER; PTHR12642; PTHR12642; 1.
DR Pfam; PF01201; Ribosomal_S8e; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..261
FT /note="Ribosome biogenesis protein nsa2"
FT /id="PRO_0000320417"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 15..22
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 52..59
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 9..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29762 MW; FFB1810DD1892E2E CRC64;
MPQNEYIERW TKQHGKRLDH DERVRKREAR QSHQQSKDAQ NLRGLRAKLY QQKRHAEKIQ
MRKRIKAQEE KNVKSSAPSE PSKTPLPQYL LDRSEATNAK ALSSAIKDKR AEKAAKFAVP
LPKVKGISEE EMFKVVNTGK KTHKKSWKRM ITKPTFVGND FTRRPVKYER FIRPMGLRYK
KANVTHPEMA VTVQLPILSV KKNPQNPLYT QLGVLTKGTV IEVNVSELGI VTAGGKVAWG
KYAQITNTPE NDGCVNAVLL V
