ID   NSA2_KLULA              Reviewed;         261 AA.
AC   Q6CNC5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Ribosome biogenesis protein NSA2;
GN   Name=NSA2; OrderedLocusNames=KLLA0E13651g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99651.1; -; Genomic_DNA.
DR   RefSeq; XP_454564.1; XM_454564.1.
DR   AlphaFoldDB; Q6CNC5; -.
DR   SMR; Q6CNC5; -.
DR   STRING; 28985.XP_454564.1; -.
DR   EnsemblFungi; CAG99651; CAG99651; KLLA0_E13619g.
DR   GeneID; 2893720; -.
DR   KEGG; kla:KLLA0_E13619g; -.
DR   eggNOG; KOG3163; Eukaryota.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q6CNC5; -.
DR   OMA; TKSWKRM; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..261
FT                   /note="Ribosome biogenesis protein NSA2"
FT                   /id="PRO_0000320418"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           15..22
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           51..58
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        9..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29646 MW;  1878A8CB500FEB28 CRC64;
     MPQNEYIEQH IKQHGRRLDH DERKRKREAR EAHKISEKAQ KLTGWKGKQF AKKRYAEKVA
     MKKKIRAHEQ SKVKGGSKPL DENGEALPTY LLDREQNNTA KAISSSIKQK RLEKADKFSV
     PLPKVRGISE EEMFKVVKTG KSKSKAWKRM ITKHTFVGEG FTRRPVKMER IIRPSALRQK
     KANVTHPELG VTVFLPILAV KKNPQSPMYT QLGVLTKGTI IEVNVSELGM VTSGGKVVWG
     KYAQITNEPD RDGCVNAVLL V