ID   NSA2_NEOFI              Reviewed;         271 AA.
AC   A1D7P0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Ribosome biogenesis protein nsa2;
GN   Name=nsa2; ORFNames=NFIA_069050;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       nop7 and rrp1. Interacts with rsa4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW21734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS027690; EAW21734.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001263631.1; XM_001263630.1.
DR   AlphaFoldDB; A1D7P0; -.
DR   SMR; A1D7P0; -.
DR   STRING; 36630.CADNFIAP00005784; -.
DR   PRIDE; A1D7P0; -.
DR   GeneID; 4590277; -.
DR   KEGG; nfi:NFIA_069050; -.
DR   eggNOG; KOG3163; Eukaryota.
DR   OrthoDB; 1079827at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..271
FT                   /note="Ribosome biogenesis protein nsa2"
FT                   /id="PRO_0000320420"
FT   REGION          22..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           25..32
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           62..69
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        22..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  31027 MW;  9543B42374ABE11E CRC64;
     MHRLLRGGHL QSFHEYIERW QKQHGKRLDH DERVRKRQAR ESHKQSQDAQ NLRGLRAKLY
     QQKRHAEKIQ MRKRIKAQEE KNVKSSAPDE PSKTPLPQYL LDRSQATNAK ALSSAIKDKR
     AEKAAKFAVP LPKVKGISEE EMFKVVNTGK KTHKKSWKRM ITKPTFVGSD FTRRPVKYER
     FIRPMGLRYK KANVTHPELG VTVQLPILGV KKNPQNPLYT QLGVLTKGTI IEVNVSELGL
     VTTSGKVVWG KYAQITNTPE NDGTVNAVLL V